Fig. 2
From: Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
Clinical features of Case 2 affected with mucopolysaccharidosis were in concert with characteristic IVCM findings. Case 2 was a Boston Terrier (female spayed) at 22 months of age. (A) Diffuse stromal cloudiness and chalky white stromal opacity associated with superficial vascularization was identified in both corneas. (B) Fourier-domain optical coherence tomography (FD-OCT) showed dense hyperreflective regions in the anterior corneal stroma in both eyes. Posterior shadowing prevented the view of posterior cornea where the deposits were dense. (C) In vivo confocal microscopy (IVCM) revealed that dense hyperreflective deposits (*) were located in the anterior corneal stroma starting immediately beneath the basal epithelium (a) and distributed multifocally in the cornea (b). Dense hyperreflective deposits appeared comprising of fine shaft or fiber-like structures (c). In the other regions where dense hyperreflective deposits were absent, keratocytes were not observed and corneal stroma appeared diffusely hyperreflective (d), which prohibited visualization of corneal endothelial cells (e)