Table 1 Cut-off points, sensitivity, specificity and area under the curve (AUC) of ROC for cfDNA Integrity Index and LOX activity during treatment of canine Transmissible venereal tumor
| Â | Baseline-1st week | Baseline-2nd week | Baseline-3rd week | 1st week-2nd week | 1st week-3rd week | 2nd week-3rd week |
|---|---|---|---|---|---|---|
cfDNA integrity index | ||||||
 Sensitivity % | 26.67 | 46.67 | 100.00 | 26.67 | 100.00 | 80.00 |
 Specificity % | 93.33 | 80.00 | 93.33 | 93.33 | 93.33 | 86.67 |
 Cut off point |  < 0.3485 |  > 0.5985 |  > 1.118 |  > 0.9070 |  > 1.022 |  > 1.329 |
 AUC of ROC % | 59.56 | 55.56 | 93.33 | 63.33 | 98.67 | 97.33 |
LOX activity | ||||||
 Sensitivity % | 60.00 | 100.00 | 100.00 | 100.00 | 100.00 | 62.50 |
 Specificity % | 70.00 | 90.00 | 90.00 | 90.00 | 90.00 | 87.50 |
 Cut off point |  < 0.6960 |  > 0.8648 |  > 0.8648 |  > 0.7396 |  > 0.7396 |  > 1.332 |
 AUC of ROC % | 58 | 100 | 100 | 100 | 100 | 81 |