Fig. 5
A Representative EIC of DOX-DNA adduct masses detected in mouse liver DNA (24 h DOX exposure). Chromatograms a and c correspond to masses found as 14N-DNA (mouse liver DNA), whereas b and d correspond to the same masses found as 15N-DNA (bacterial DNA spiked into the sample prior to processing). B Time course of DOX-DNA adduct formation for m/z 680.1830, 809.2622 and their 15N-labeled counterparts (m/z 685.1683 and 814.2474). Peak areas were normalized by DNA amounts (derived by measuring amounts of dG)