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Table 6 Urine-specific gravity and urine electrolyte excretion after furosemide (2 mg/kg) administration

From: Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

  Baseline Time (h)
1 2 4 6 8
Urine-specific gravity IV 1.040 ± 0.010 1.012 ± 0.002** 1.007 ± 0.001** 1.011 ± 0.002** 1.020 ± 0.004* 1.030 ± 0.007
OUT 1.039 ± 0.009 1.032 ± 0.015** 1.012 ± 0.006** 1.010 ± 0.003** 1.017 ± 0.006* 1.022 ± 0.007
FS-ODF 1.045 ± 0.007 1.022 ± 0.013* 1.009 ± 0.002** 1.014 ± 0.005** 1.020 ± 0.010* 1.025 ± 0.009*
Urine sodium excretion per hour (mmol/h) IV 0.64 ± 0.56 17.75 ± 7.21** 8.70 ± 3.52** 0.95 ± 0.47 0.52 ± 0.21 0.35 ± 0.21
OUT 0.95 ± 1.05 11.13 ± 11.67** 18.88 ± 10.01** 3.77 ± 1.77 1.22 ± 0.52 0.44 ± 0.22
FS-ODF 0.93 ± 0.56 8.63 ± 4.63* 17.18 ± 12.01* 1.96 ± 0.94 0.78 ± 0.24 0.48 ± 0.11
Urine potassium excretion per hour (mmol/h) IV 0.31 ± 0.16 3.51 ± 1.17** 1.11 ± 0.32** 0.21 ± 0.10 0.16 ± 0.06 0.16 ± 0.11
OUT 0.92 ± 1.12 4.48 ± 4.48** 2.46 ± 1.24** 0.63 ± 0.26 0.33 ± 0.18 0.14 ± 0.06
FS-ODF 0.79 ± 0.53 2.40 ± 0.67* 2.70 ± 1.38* 0.41 ± 0.21 0.24 ± 0.13 0.16 ± 0.06
Urine chloride excretion per hour (mmol/h) IV 0.43 ± 0.11 11.43 ± 3.04** 5.72 ± 1.33** 0.72 ± 0.33 0.32 ± 0.12 0.19 ± 0.08**
OUT 1.04 ± 1.29 8.48 ± 9.14** 10.29 ± 4.41** 2.63 ± 1.36 0.84 ± 0.38 0.25 ± 0.09**
FS-ODF 0.76 ± 0.47 4.89 ± 2.62* 9.60 ± 5.21* 1.39 ± 0.62 0.53 ± 0.23 0.30 ±0.09
  1. Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline