| Baseline | Time (h) | |||||
---|---|---|---|---|---|---|---|
1 | 2 | 4 | 6 | 8 | |||
Urine-specific gravity | IV | 1.040 ± 0.010 | 1.012 ± 0.002** | 1.007 ± 0.001** | 1.011 ± 0.002** | 1.020 ± 0.004* | 1.030 ± 0.007 |
OUT | 1.039 ± 0.009 | 1.032 ± 0.015** | 1.012 ± 0.006** | 1.010 ± 0.003** | 1.017 ± 0.006* | 1.022 ± 0.007 | |
FS-ODF | 1.045 ± 0.007 | 1.022 ± 0.013* | 1.009 ± 0.002** | 1.014 ± 0.005** | 1.020 ± 0.010* | 1.025 ± 0.009* | |
Urine sodium excretion per hour (mmol/h) | IV | 0.64 ± 0.56 | 17.75 ± 7.21** | 8.70 ± 3.52** | 0.95 ± 0.47 | 0.52 ± 0.21 | 0.35 ± 0.21 |
OUT | 0.95 ± 1.05 | 11.13 ± 11.67** | 18.88 ± 10.01** | 3.77 ± 1.77 | 1.22 ± 0.52 | 0.44 ± 0.22 | |
FS-ODF | 0.93 ± 0.56 | 8.63 ± 4.63* | 17.18 ± 12.01* | 1.96 ± 0.94 | 0.78 ± 0.24 | 0.48 ± 0.11 | |
Urine potassium excretion per hour (mmol/h) | IV | 0.31 ± 0.16 | 3.51 ± 1.17** | 1.11 ± 0.32** | 0.21 ± 0.10 | 0.16 ± 0.06 | 0.16 ± 0.11 |
OUT | 0.92 ± 1.12 | 4.48 ± 4.48** | 2.46 ± 1.24** | 0.63 ± 0.26 | 0.33 ± 0.18 | 0.14 ± 0.06 | |
FS-ODF | 0.79 ± 0.53 | 2.40 ± 0.67* | 2.70 ± 1.38* | 0.41 ± 0.21 | 0.24 ± 0.13 | 0.16 ± 0.06 | |
Urine chloride excretion per hour (mmol/h) | IV | 0.43 ± 0.11 | 11.43 ± 3.04** | 5.72 ± 1.33** | 0.72 ± 0.33 | 0.32 ± 0.12 | 0.19 ± 0.08** |
OUT | 1.04 ± 1.29 | 8.48 ± 9.14** | 10.29 ± 4.41** | 2.63 ± 1.36 | 0.84 ± 0.38 | 0.25 ± 0.09** | |
FS-ODF | 0.76 ± 0.47 | 4.89 ± 2.62* | 9.60 ± 5.21* | 1.39 ± 0.62 | 0.53 ± 0.23 | 0.30 ±0.09 |