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Table 6 Urine-specific gravity and urine electrolyte excretion after furosemide (2 mg/kg) administration

From: Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

 

Baseline

Time (h)

1

2

4

6

8

Urine-specific gravity

IV

1.040 ± 0.010

1.012 ± 0.002**

1.007 ± 0.001**

1.011 ± 0.002**

1.020 ± 0.004*

1.030 ± 0.007

OUT

1.039 ± 0.009

1.032 ± 0.015**

1.012 ± 0.006**

1.010 ± 0.003**

1.017 ± 0.006*

1.022 ± 0.007

FS-ODF

1.045 ± 0.007

1.022 ± 0.013*

1.009 ± 0.002**

1.014 ± 0.005**

1.020 ± 0.010*

1.025 ± 0.009*

Urine sodium excretion per hour (mmol/h)

IV

0.64 ± 0.56

17.75 ± 7.21**

8.70 ± 3.52**

0.95 ± 0.47

0.52 ± 0.21

0.35 ± 0.21

OUT

0.95 ± 1.05

11.13 ± 11.67**

18.88 ± 10.01**

3.77 ± 1.77

1.22 ± 0.52

0.44 ± 0.22

FS-ODF

0.93 ± 0.56

8.63 ± 4.63*

17.18 ± 12.01*

1.96 ± 0.94

0.78 ± 0.24

0.48 ± 0.11

Urine potassium excretion per hour (mmol/h)

IV

0.31 ± 0.16

3.51 ± 1.17**

1.11 ± 0.32**

0.21 ± 0.10

0.16 ± 0.06

0.16 ± 0.11

OUT

0.92 ± 1.12

4.48 ± 4.48**

2.46 ± 1.24**

0.63 ± 0.26

0.33 ± 0.18

0.14 ± 0.06

FS-ODF

0.79 ± 0.53

2.40 ± 0.67*

2.70 ± 1.38*

0.41 ± 0.21

0.24 ± 0.13

0.16 ± 0.06

Urine chloride excretion per hour (mmol/h)

IV

0.43 ± 0.11

11.43 ± 3.04**

5.72 ± 1.33**

0.72 ± 0.33

0.32 ± 0.12

0.19 ± 0.08**

OUT

1.04 ± 1.29

8.48 ± 9.14**

10.29 ± 4.41**

2.63 ± 1.36

0.84 ± 0.38

0.25 ± 0.09**

FS-ODF

0.76 ± 0.47

4.89 ± 2.62*

9.60 ± 5.21*

1.39 ± 0.62

0.53 ± 0.23

0.30 ±0.09

  1. Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline