| |
Baseline
|
Time (h)
|
---|
1
|
2
|
4
|
6
|
8
|
---|
Hourly urinary output (ml/h)
|
IV
|
8.45 ± 2.82
|
147.20 ± 34.05**
|
74.60 ± 15.61**
|
9.70 ± 3.93
|
7.10 ± 3.11
|
6.20 ± 3.68
|
OUT
|
16.40 ± 22.28
|
88.80 ± 94.10**
|
128.80 ± 51.09**
|
34.30 ± 16.90
|
13.50 ± 5.51
|
6.60 ± 4.59
|
FS-ODF
|
12.66 ± 6.97
|
71.40 ± 41.93*
|
121.20 ± 61.49*
|
18.0 ± 8.96
|
9.40 ± 4.48
|
6.70 ± 2.31
|
Accumulatedurinary output (ml)
|
IV
|
13.0 ± 4.53
|
160.20 ± 37.16**
|
234.80 ± 47.07**
|
254.20 ± 51.28**
|
268.4 ± 57.05**
|
288.6 ± 55.76**
|
OUT
|
26.20 ± 32.22
|
115.0 ± 124.80**
|
243.80 ± 151.63**
|
312.40 ± 139.36**
|
339.4 ± 135.60**
|
359.8 ± 134.75**
|
FS-ODF
|
27.0 ± 16.90
|
98.40 ± 41.97*
|
219.60 ± 89.41**
|
255.60 ± 91.68**
|
274.40 ± 87.68**
|
293.60 ± 99.60**
|
- Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline