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Table 5 Hourly urine output and cumulative urine output after furosemide administration via different routes

From: Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

   Baseline Time (h)
1 2 4 6 8
Hourly urinary output (ml/h) IV 8.45 ± 2.82 147.20 ± 34.05** 74.60 ± 15.61** 9.70 ± 3.93 7.10 ± 3.11 6.20 ± 3.68
OUT 16.40 ± 22.28 88.80 ± 94.10** 128.80 ± 51.09** 34.30 ± 16.90 13.50 ± 5.51 6.60 ± 4.59
FS-ODF 12.66 ± 6.97 71.40 ± 41.93* 121.20 ± 61.49* 18.0 ± 8.96 9.40 ± 4.48 6.70 ± 2.31
Accumulatedurinary output (ml) IV 13.0 ± 4.53 160.20 ± 37.16** 234.80 ± 47.07** 254.20 ± 51.28** 268.4 ± 57.05** 288.6 ± 55.76**
OUT 26.20 ± 32.22 115.0 ± 124.80** 243.80 ± 151.63** 312.40 ± 139.36** 339.4 ± 135.60** 359.8 ± 134.75**
FS-ODF 27.0 ± 16.90 98.40 ± 41.97* 219.60 ± 89.41** 255.60 ± 91.68** 274.40 ± 87.68** 293.60 ± 99.60**
  1. Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline