Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

Table 5 Hourly urine output and cumulative urine output after furosemide administration via different routes

		Baseline	Time (h)
		Baseline	1	2	4	6	8
Hourly urinary output (ml/h)	IV	8.45 ± 2.82	147.20 ± 34.05^**	74.60 ± 15.61^**	9.70 ± 3.93	7.10 ± 3.11	6.20 ± 3.68
	OUT	16.40 ± 22.28	88.80 ± 94.10^**	128.80 ± 51.09^**	34.30 ± 16.90	13.50 ± 5.51	6.60 ± 4.59
	FS-ODF	12.66 ± 6.97	71.40 ± 41.93^*	121.20 ± 61.49^*	18.0 ± 8.96	9.40 ± 4.48	6.70 ± 2.31
Accumulatedurinary output (ml)	IV	13.0 ± 4.53	160.20 ± 37.16^**	234.80 ± 47.07^**	254.20 ± 51.28^**	268.4 ± 57.05^**	288.6 ± 55.76^**
	OUT	26.20 ± 32.22	115.0 ± 124.80^**	243.80 ± 151.63^**	312.40 ± 139.36^**	339.4 ± 135.60^**	359.8 ± 134.75^**
	FS-ODF	27.0 ± 16.90	98.40 ± 41.97^*	219.60 ± 89.41^**	255.60 ± 91.68^**	274.40 ± 87.68^**	293.60 ± 99.60^**

Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline

ISSN: 1746-6148