Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

Table 4 Serum electrolyte concentration following furosemide (2 mg/kg) administration in beagle dogs

		Baseline	Time (h)
		Baseline	1	2	4	6	8
Serum sodium excretion (mmol)	IV	151.26 ± 4.06	148.14 ± 1.46	148.04 ± 1.13	150.60 ± 2.10	147.74 ± 4.79	148.52 ± 1.30
	OUT	150.34 ± 2.62	153.56 ± 7.59	150.14 ± 1.48	149.12 ± 1.08	151.92 ± 5.29	149.84 ± 1.44
	FS-ODF	150.94 ± 2.97	155.20 ± 9.26	150.06 ± 2.12	148.98 ± 6.06	153.46 ± 9.29	148.56 ± 1.09
Serum potassium excretion (mmol)	IV	4.48 ± 0.15	4.19 ± 0.17^*	3.97 ± 0.29^**	4.12 ± 0.29^**	4.04 ± 0.31^**	4.15 ± 0.42
	OUT	4.51 ± 0.34	4.43 ± 0.41^*	3.97 ± 0.14^**	4.05 ± 0.23^**	4.04 ± 0.28^**	4.05 ± 0.27
	FS-ODF	4.43 ± 0.32	4.08 ± 0.36^**	3.92 ± 0.28^**	4.09 ± 0.37^**	4.13 ± 0.41^*	4.05 ± 0.23^*
Serum chloride excretion (mmol)	IV	110.66 ± 4.20	106.46 ± 1.41	105.96 ± 1.33^*	107.64 ± 2.01	104.34 ± 4.25	106.36 ± 0.80
	OUT	110.28 ± 3.38	111.56 ± 8.26	107.52 ± 1.61^*	105.88 ± 0.58	107.76 ± 3.43	106.50 ± 1.35
	FS-ODF	110.22 ± 3.30	112.74 ± 7.69	106.84 ± 1.82	106.04 ± 4.56	109.96 ± 7.89	106.20 ± 1.08

Results are presented as mean ± SD. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline

ISSN: 1746-6148