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Table 4  Serum electrolyte concentration following furosemide (2 mg/kg) administration in beagle dogs

From: Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

  Baseline Time (h)
1 2 4 6 8
Serum sodium excretion (mmol) IV 151.26 ± 4.06 148.14 ± 1.46 148.04 ± 1.13 150.60 ± 2.10 147.74 ± 4.79 148.52 ± 1.30
OUT 150.34 ± 2.62 153.56 ± 7.59 150.14 ± 1.48 149.12 ± 1.08 151.92 ± 5.29 149.84 ± 1.44
FS-ODF 150.94 ± 2.97 155.20 ± 9.26 150.06 ± 2.12 148.98 ± 6.06 153.46 ± 9.29 148.56 ± 1.09
Serum potassium excretion (mmol) IV 4.48 ± 0.15 4.19 ± 0.17* 3.97 ± 0.29** 4.12 ± 0.29** 4.04 ± 0.31** 4.15 ± 0.42
OUT 4.51 ± 0.34 4.43 ± 0.41* 3.97 ± 0.14** 4.05 ± 0.23** 4.04 ± 0.28** 4.05 ± 0.27
FS-ODF 4.43 ± 0.32 4.08 ± 0.36** 3.92 ± 0.28** 4.09 ± 0.37** 4.13 ± 0.41* 4.05 ± 0.23*
Serum chloride excretion (mmol) IV 110.66 ± 4.20 106.46 ± 1.41 105.96 ± 1.33* 107.64 ± 2.01 104.34 ± 4.25 106.36 ± 0.80
OUT 110.28 ± 3.38 111.56 ± 8.26 107.52 ± 1.61* 105.88 ± 0.58 107.76 ± 3.43 106.50 ± 1.35
FS-ODF 110.22 ± 3.30 112.74 ± 7.69 106.84 ± 1.82 106.04 ± 4.56 109.96 ± 7.89 106.20 ± 1.08
  1. Results are presented as mean ± SD. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline