Skip to main content

Table 3 Hematocrit and biochemistry profile following single dose of furosemide (2 mg/kg) administration

From: Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

 

Baseline

Time (h)

1

2

4

6

8

Hematocrit(%)

IV

40.46 ± 9.43

41.36 ± 5.43

38.52 ± 6.84

39.06 ± 7.43

39.02 ± 6.01

40.22 ± 5.35

OUT

38.98 ± 4.18

39.10 ± 3.16

38.52 ± 3.50

38.64 ± 3.75

38.72 ± 4.04

40.12 ± 3.94

FS-ODF

41.94 ± 5.19

41.02 ± 6.17

40.20 ± 6.48

41.44 ± 4.21

41.58 ± 6.30

40.54 ± 7.81

BUN (mg/dL)

IV

17.10 ± 6.33

17.50 ± 5.60**

17.20 ± 5.57**

16.72 ± 5.25

16.20 ± 5.21

15.94 ± 5.23

OUT

21.84 ± 9.99

20.82 ± 9.12**

20.22 ± 8.99

19.04 ± 7.96

17.52 ± 6.25

16.60 ± 5.83

FS-ODF

18.96 ± 6.39

18.68 ± 6.15**

18.16 ± 6.10

17.30 ± 5.90**

16.14 ± 5.28*

15.41 ± 4.72*

Cr (mg/dL)

IV

0.72 ± 0.24

0.68 ± 0.19

0.68 ± 0.24

0.68 ± 0.19

0.72 ± 0.13

0.68 ± 0.23

OUT

0.72 ± 0.29

0.70 ± 0.25

0.68 ± 0.23

0.66 ± 0.23

0.68 ± 0.16

0.66 ± 0.18

FS-ODF

0.72 ± 0.13

0.74 ± 0.19

0.68 ± 0.22

0.70 ± 0.19

0.72 ± 0.19

0.70 ± 0.20

Total protein (mg/dL)

IV

5.90 ± 0.36

6.32 ± 0.29**

6.18 ± 0.36**

6.10 ± 0.30*

6.04 ± 0.25

6.04 ± 0.34*

OUT

5.74 ± 0.29

6.02 ± 0.25**

6.10 ± 0.38**

6.10 ± 0.31*

5.94 ± 0.34

6.00 ± 0.29*

FS-ODF

6.06 ± 0.18

6.30 ± 0.10**

6.38 ± 0.18**

6.26 ± 0.17*

6.30 ± 0.20

6.34 ± 0.05*

  1. Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film, BUN Blood urea nitrogen, Cr Creatinine. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline