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Table 3 Hematocrit and biochemistry profile following single dose of furosemide (2 mg/kg) administration

From: Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs

  Baseline Time (h)
1 2 4 6 8
Hematocrit(%) IV 40.46 ± 9.43 41.36 ± 5.43 38.52 ± 6.84 39.06 ± 7.43 39.02 ± 6.01 40.22 ± 5.35
OUT 38.98 ± 4.18 39.10 ± 3.16 38.52 ± 3.50 38.64 ± 3.75 38.72 ± 4.04 40.12 ± 3.94
FS-ODF 41.94 ± 5.19 41.02 ± 6.17 40.20 ± 6.48 41.44 ± 4.21 41.58 ± 6.30 40.54 ± 7.81
BUN (mg/dL) IV 17.10 ± 6.33 17.50 ± 5.60** 17.20 ± 5.57** 16.72 ± 5.25 16.20 ± 5.21 15.94 ± 5.23
OUT 21.84 ± 9.99 20.82 ± 9.12** 20.22 ± 8.99 19.04 ± 7.96 17.52 ± 6.25 16.60 ± 5.83
FS-ODF 18.96 ± 6.39 18.68 ± 6.15** 18.16 ± 6.10 17.30 ± 5.90** 16.14 ± 5.28* 15.41 ± 4.72*
Cr (mg/dL) IV 0.72 ± 0.24 0.68 ± 0.19 0.68 ± 0.24 0.68 ± 0.19 0.72 ± 0.13 0.68 ± 0.23
OUT 0.72 ± 0.29 0.70 ± 0.25 0.68 ± 0.23 0.66 ± 0.23 0.68 ± 0.16 0.66 ± 0.18
FS-ODF 0.72 ± 0.13 0.74 ± 0.19 0.68 ± 0.22 0.70 ± 0.19 0.72 ± 0.19 0.70 ± 0.20
Total protein (mg/dL) IV 5.90 ± 0.36 6.32 ± 0.29** 6.18 ± 0.36** 6.10 ± 0.30* 6.04 ± 0.25 6.04 ± 0.34*
OUT 5.74 ± 0.29 6.02 ± 0.25** 6.10 ± 0.38** 6.10 ± 0.31* 5.94 ± 0.34 6.00 ± 0.29*
FS-ODF 6.06 ± 0.18 6.30 ± 0.10** 6.38 ± 0.18** 6.26 ± 0.17* 6.30 ± 0.20 6.34 ± 0.05*
  1. Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film, BUN Blood urea nitrogen, Cr Creatinine. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline