| |
Baseline
|
Time (h)
|
|---|
|
1
|
2
|
4
|
6
|
8
|
|---|
|
Hematocrit(%)
|
IV
|
40.46 ± 9.43
|
41.36 ± 5.43
|
38.52 ± 6.84
|
39.06 ± 7.43
|
39.02 ± 6.01
|
40.22 ± 5.35
|
|
OUT
|
38.98 ± 4.18
|
39.10 ± 3.16
|
38.52 ± 3.50
|
38.64 ± 3.75
|
38.72 ± 4.04
|
40.12 ± 3.94
|
|
FS-ODF
|
41.94 ± 5.19
|
41.02 ± 6.17
|
40.20 ± 6.48
|
41.44 ± 4.21
|
41.58 ± 6.30
|
40.54 ± 7.81
|
|
BUN (mg/dL)
|
IV
|
17.10 ± 6.33
|
17.50 ± 5.60**
|
17.20 ± 5.57**
|
16.72 ± 5.25
|
16.20 ± 5.21
|
15.94 ± 5.23
|
|
OUT
|
21.84 ± 9.99
|
20.82 ± 9.12**
|
20.22 ± 8.99
|
19.04 ± 7.96
|
17.52 ± 6.25
|
16.60 ± 5.83
|
|
FS-ODF
|
18.96 ± 6.39
|
18.68 ± 6.15**
|
18.16 ± 6.10
|
17.30 ± 5.90**
|
16.14 ± 5.28*
|
15.41 ± 4.72*
|
|
Cr (mg/dL)
|
IV
|
0.72 ± 0.24
|
0.68 ± 0.19
|
0.68 ± 0.24
|
0.68 ± 0.19
|
0.72 ± 0.13
|
0.68 ± 0.23
|
|
OUT
|
0.72 ± 0.29
|
0.70 ± 0.25
|
0.68 ± 0.23
|
0.66 ± 0.23
|
0.68 ± 0.16
|
0.66 ± 0.18
|
|
FS-ODF
|
0.72 ± 0.13
|
0.74 ± 0.19
|
0.68 ± 0.22
|
0.70 ± 0.19
|
0.72 ± 0.19
|
0.70 ± 0.20
|
|
Total protein (mg/dL)
|
IV
|
5.90 ± 0.36
|
6.32 ± 0.29**
|
6.18 ± 0.36**
|
6.10 ± 0.30*
|
6.04 ± 0.25
|
6.04 ± 0.34*
|
|
OUT
|
5.74 ± 0.29
|
6.02 ± 0.25**
|
6.10 ± 0.38**
|
6.10 ± 0.31*
|
5.94 ± 0.34
|
6.00 ± 0.29*
|
|
FS-ODF
|
6.06 ± 0.18
|
6.30 ± 0.10**
|
6.38 ± 0.18**
|
6.26 ± 0.17*
|
6.30 ± 0.20
|
6.34 ± 0.05*
|
- Data are described as mean ± SD values. IV intravenous, OUT orally uncoated tablet, FS-ODF furosemide-loaded orally disintegrating film, BUN Blood urea nitrogen, Cr Creatinine. The p-values are significantly different (*p < 0.05, **p < 0.01) compared to the baseline
