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Table 4 The pharmacokinetic parameters of myrislignan in mice following oral or intraperitoneal administration (n = 6)

From: Determination of myrislignan levels in BALB/c mouse plasma by LC-MS/MS and a comparison of its pharmacokinetics after oral and intraperitoneal administration

Parameters (Units) Mean ± SD
Intraperitoneal Oral
Kel (h− 1) 1.19 ± 0.443 0.366 ± 0.0789
T1/2 (h) 0.692 ± 0.386 1.97 ± 0.426
Tmax (h) 0.167 ± 0.0915 1.04 ± 1.45
Cmax (ng/mL) 3870 ± 1200 105 ± 72.3
Cl_Fobs(mL/hr/kg) 45,123 ± 11,936 302,900 ± 442,668
Vz_Fobs(mL/kg) 24,198 ± 5987 970,149 ± 199,518
AUC0 − t (h/ng/mL) 2050 ± 532 157 ± 55.1
AUC0 − inf (h/ng/mL) 2060 ± 536 162 ± 52.9
AUMClast (hr*hr*ng/mL) 1006 ± 227 457 ± 240
MRT0 − t (h) 0.457 ± 0.0499 2.19 ± 0.841
MRT0 − inf (h) 0.466 ± 0.0485 2.57 ± 0.858
 F* = 1.97 %