Table 4 Hematology and serum biochemistry of dogs fed diets supplemented with silybin and commercial hepatoprotectant (EXP1)

WBC (×  10⁹/L)

10.5^a

8.84^b

9.02^b

0.02

NEUT (× 10⁹/L)

6.99^a

5.51^b

5.37^b

0.01

LYM (×  10⁹/L)

2.15

2.50

2.58

NSD

MONO (× 10⁹/L)

0.90^a

0.65^b

.74^ab

0.03

EOS (× 10⁹/L)

0.45^a

0.15^b

.29^ab

0.03

BASO (× 10⁹/L)

0.04

0.04

.03

NSD

RBC (×  10¹²/L)

6.81

6.79

6.92

NSD

HEM (g/L)

160

164

166

NSD

HTC (%)

0.46

0.47

0.47

NSD

MCV (fL/cell)

67.9

68.7

68.5

NSD

MCH (pg/cell)

23.5^b

24.1^a

24.0^a

0.001

MCHC (g/L)

346

352

350

NSD

PLT (× 10⁹/L)

219

245

241

NSD

Albumin (g/L)

3.7

3.6

31.0

NSD

ALT (U/L)

37.7

39.0

36.1

NSD

Alpha-Amylase (U/L)

752^a

467^b

593^b

<  0.001

ALP (U/L)

42.6^a

35.4^b

31.2^b

<  0.001

AST (U/L)

28.6

32.6

32.2

NSD

Total protein (g/L)

58.2

59.6

59.4

NSD

Total bilirubin (μmol/l)

2.94^b

3.39^a

3.03^ab

0.04

Cholesterol (mmol/L)

4.28

4.61

4.69

NSD

CK (U/L)

152

154

154

NSD

Fructosamine (μmol/l)

242^b

265^a

258^ab

0.01

GLDH (U/L)

2.98

3.40

3.27

NSD

GLUC (mmol/L)

6.18^a

5.09^b

5.42^b

<  0.001

GGT (U/L)

2.30^b

4.08^a

3.32^a

<  0.001

Creatinine (μmol/l)

71.8

67.5

68.0

NSD

LDH (U/L)

157

141.1

146

NSD

Lipase (DGGR) (U/L)

58.8

68.0

76.5

NSD

Urea (mmol/L)

3.98

4.60

4.48

NSD

TG (mmol/L)

0.42^b

0.59^a

0.54^a

<  0.001

Chloride (mmol/L)

114

112

113

NSD

Inorganic phosphorus (mmol/L)

1.31

1.52

1.52

NSD

Magnesium (mmol/L)

0.70^b

0.79^a

0.80^a

<  0.001

Potassium (mmol/L)

4.17^b

4.52^a

4.54^a

<  0.001

Sodium (mmol/L)

148

146

147

0.05

Calcium (mmol/L)

2.56^a

2.44^b

2.50^ab

0.001

Albumin / globulin ratio

1.12

1.07

1.11

NSD

Globulin (g/L)

27.5

29.0

28.4

NSD