Table 1 Non-compartmental pharmacokinetic parameters of oral 5-FC (100 mg/kg, twice daily) at days 1 and 7
From: Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs
Parameter | Unit | Day 1 | Day 7 |
|---|---|---|---|
Elimination rate constant (λz) | min− 1 | 0.0043 ± 0.0005 | 0.0039 ± 0.0002 |
Elimination half-life (t1/2) | min | 163.1 ± 20.3 | 177.8 ± 11.0 |
Time to maximum plasma concentration (Tmax) | min | 100 ± 17 | 120 ± 2 |
Maximum plasma concentration (Cmax) | µg/ml | 84.5 ± 7.1 | 89.7 ± 12.3 |
Area under the concentration time curve (AUC0 − inf) | µg.min/ml | 24 916 ± 2 076 | 30 174 ± 2 103* |
Apparent volume of distribution at pseudo-equilibrium (Vz/F_obs) | ml/kg | 936.9 ± 66.2 | 844.9 ± 25.7 |
Apparent clearance (Cl/F_obs) | ml/min/kg | 4.0 ± 0.3 | 3.3 ± 0.2* |