Table 4 Results Cox proportional hazard regression with the different outcome evaluations. BM – Belgian Malinois; CBPI – Canine Brief Pain Inventory; COI – Canine Orthopedic Index; DSD – Dutch Shepherd Dogs; GSD – German Shepherd Dogs; HVAS – Hudson Visual Analogue Scale; LOAD – Liverpool Osteoarthritis in Dogs; LR – Labrador Retriever; OFA – Orthopedic Foundation for Animals; PG – PRP group; PIS – Pain Interference Score; PSS – Pain Severity Score; QOL – Quality of Life. * indicates significance
From: Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis
Variable | HVAS (p = 0.001*) | CBPI | LOAD (p = 0.009*) | |||||||
PSS (p = 0.006*) | PIS (p = 0.002*) | |||||||||
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |||
Treatment | ||||||||||
 PG | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | ||
 Control | 6.64 (1.96–22.45) | 0.00* | 1.82 (0.75–4.41) | 0.02* | 6.61 (1.97–22.19) | 0.00* | 5.44 (1.84–16.03) | 0.002* | ||
OFA score | ||||||||||
 Moderate | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | ||
 Severe | 1.56 (0.59–4.18) | 0.37 | 0.86 (0.34–2.18) | 0.75 | 0.62 (0.23–1.64) | 0.33 | 1.08 (0.38–3.05) | 0.89 | ||
 Breed |  | 0.531 |  |  |  |  |  |  | ||
 GSD | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | ||
 BM | 2.02 (0.42–9.67) | 0.38 | 0.93 (0.19–4.66) | 0.93 | 1.46 (0.31–6.98) | 0.64 | 2.87 (0.56–14.7) | 0.21 | ||
 LR | 0.63 (0.21–1.91) | 0.98 | 0.44 (0.13–1.54) | 0.98 | 0.58 (0.13–2.72) | 0.98 | 0.99 (0.56–1.24) | 0.98 | ||
 DSD | 0.94 (0.17–5.19) | 0.95 | 0.36 (0.06–2.33) | 0.28 | 0.86 (0.16–4.71) | 0.87 | 1.27 (0.24–6.89) | 0.78 | ||
Sex | ||||||||||
 Male | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | ||
 Female | 0.53 (0.21–1.34) | 0.18 | 0.50 (0.19–1.34) | 0.17 | 0.41 (0.15–1.08) | 0.07 | 3.07 (1.03–9.19) | 0.05 | ||
 Bodyweight | 1.01 (0.96–1.08) | 0.65 | 1.06 (1.00–1.13) | 0.04* | 1.03 (0.97–1.10) | 0.34 | 0.98 (0.91–1.05) | 0.59 | ||
 Age | 1.15 (0.92–1.45) | 0.39 | 1.28 (0.97–1.69) | 0.08 | 0.98 (0.79–1.22) | 0.85 | 1.03 (0.81–1.29) | 0.84 | ||
Variable | Stiffness (p = 0.018*) | Function (p = 0.178) | COI Gait (p = 0.001*) | QOL (p = 0.002*) | Total (p = 0.001*) | |||||
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
Treatment | ||||||||||
 PG | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  |
 Control | 4.46 (1.55–12.8) | 0.01* | 2.80 (1.00–7.83) | 0.04* | 10.72 (2.19–52.5) | 0.003* | 3.33 (1.21–9.22) | 0.02* | 3.88 (1.38–10.9) | 0.01* |
OFA score | ||||||||||
 Moderate | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  |
 Severe | 0.81 (0.35–1.90) | 0.63 | 1.21 (0.47–3.09) | 0.69 | 1.76 (0.70–4.40) | 0.23 | 2.96 (1.15–7.62) | 0.02* | 3.02 (1.21–7.56) | 0.02* |
Breed | ||||||||||
 GSD | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  |
 BM | 1.86 (0.40–8.64 | 0.43 | 2.44 (0.53–11.16) | 0.25 | 0.17 (0.03–0.83) | 0.92 | 1.25 (0.26–6.08) | 0.78 | 4.67 (0.92–23.67) | 0.06 |
 LR | 1.42 (0.36–5.61) | 0.98 | 0.46 (0.14–1.58) | 0.98 | 0.35 (0.09–1.33) | 0.99 | 1.39 (0.40–4.81) | 0.98 | 1.15 (0.33–3.96) | 0.98 |
 DSD | 0.89 (0.15–5.09) | 0.89 | 1.12 (0.21–6.10) | 0.89 | 0.76 (0.21–2.76) | 0.92 | 0.64 (0.11–3.89) | 0.63 | 1.73 (0.28–10.54) | 0.55 |
Sex | ||||||||||
 Male | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  | 1.00 |  |
 Female | 0.97 (0.39–2.40) | 0.94 | 1.14 (0.39–3.28) | 0.80 | 0.45 (0.17–1.17) | 0.10 | 0.29 (0.10–0.83) | 0.21 | 0.35 (0.16–0.97) | 0.04* |
 Bodyweight | 1.01 (0.95–1.07) | 0.86 | 0.96 (0.89–1.02) | 0.20 | 1.01 (0.94–1.08) | 0.83 | 1.03 (0.96–1.09) | 0.39 | 0.99 (0.94–1.07) | 0.98 |
 Age | 1.05 (0.85–1.29) | 0.65 | 0.95 (0.77–1.18) | 0.65 | 1.00 (0.81–1.24) | 0.99 | 1.15 (0.92–1.44) | 0.21 | 1.23 (0.99–1.52) | 0.07 |