Fig. 8

Prediction interval (90%) for plasma exposure following a constant rate infusion using a subpalpebral lavage system (SPL) at 5 μg/kg per 24 h vs. a series of administered topical ophthalmic solution (eye drops) at 0.5 μg/kg at 6 h intervals. Solid horizontal lines represent the 5, 50 and 95th quantile of a population of 1000 horses obtained by Monte Carlo Simulation with 90% of horses ranging between average plasma concentrations of 0.053 μ/L (lower solid line) and 0.108 μ/L (upper solid line). Broken line corresponds to simulated atropine plasma concentration-time course after 0.5 μg/kg atropine administered as topical ophthalmic solution at 6 h interval. The simulation was based on typical values of the primary structural parameters of the model (thetas)