Fig. 5

Visual Prediction Check according to route of administration: single intravenous administration (IV) (left), single administration of an ophthalmic solution (eye drops) (middle) and constant rate infusion using a subpalpebral lavage system (SPL) (right). The empirical and predicted 20th and 80th percentiles are shown in solid red and black lines respectively. The observed and predicted 50th percentile (median) are shown in red and black broken lines respectively. The black dots are observed data. A binning option with explicit centers was used to generate these plots