Fig. 2
From: Aquaporin-4 protein expression in normal canine brains
CNS AQP4 immunoreactivity comparison between dogs of varied ages at a different representative encephalic structure in transverse sections. Parietal/temporal cortex (1) (0.5 times magnification), Midbrain/pons (2) (0.6-1x), Archicortex with hippocampal formation (3) (2-2.5 times magnification) and Cerebellar cortex (4) (10-15 times magnification). The youngest dogs (a: N01 and N02) showed a generalized AQP4 labeling diffusively involving the neuroparenchyma. The adult and senior dogs (b and c: N05,N06, N10 and N11) presented greater expression of AQP4 in the subcortical WM and at the interface between major fluid compartments (periventricular and subpial surfaces). The hippocampal distribution in b and c was concentrated in the GM of the dentate gyrus and Amon’s horn