Respiratory viral infections drive different lung cytokine profiles in pigs

BMC Veterinary Research

Table 3 The relationship between concentration of cytokines in the lung parenchyma and lung pathogen load after single or dual inoculation with IAV and/or PRRSV

Group	Pathogen load	Spearman’s rank correlation coefficient (R-Spearman)
Group	Pathogen load	IFN-α	IFN-ɣ	TNF-α	IL-1β	IL-6	IL-8	IL-10
IAV	SwH1N1	0.43	0.77*	0.86*	0.08	0.45	0.62*	0.40
PRRSV	PRRSV	0.07	0.02	0.33	0.42	0.35	0.62*	0.33
IAV + PRRSV	PRRSV SwH1N1	0.41 0.23	0.37 0.81*	0.54* 0.77*	0.09 0.59	0.04 0.23	0.38* 0.63*	0.30 0.20

IAV pigs inoculated with swine influenza A virus, PRRSV pigs inoculated with porcine reproduction and respiratory syndrome virus, IAV + PRRSV pigs co-inoculated with PRRSV and IAV; * a statistically significant correlation with a p-value less than 0.05

ISSN: 1746-6148