Skip to main content

Table 1 Multidrug Resistance Direct Dye Efflux Activity in CIPp and CIPm

From: Doxorubicin treatment modulates chemoresistance and affects the cell cycle in two canine mammary tumour cell lines

  CIPp CIPm
  Δ (N-P) MFI Δ (P-V) MFI Δ (N-P) MFI Δ (P-V) MFI
15 min 43.87 ± 5.74 −33.34 ± 5.68* 41.55 ± 5.69 − 14.49 ± 5.38*
1 h 60.15 ± 5.81 −34.09 ± 5.33 59.75 ± 6.15 −29.15 ± 6.11
4 h 81.32 ± 5.25 −28.25 ± 6.01* 86.71 ± 5.13 −9.70 ± 5.08*
24 h 101.06 ± 4.98 − 13.58 ± 5.12* 101.47 ± 4.85 −3.49 ± 2.54*
  1. Differences (Δ) between median fluorescence intensity (MFI) values: ΔN-P (negative controls at 4 °C - positive controls at 37 °C) represents the amount of fluorescent dye effluxed at each time point, ΔP-V (positive controls at 37 °C - cells treated with Vinblastine at 37 °C) represents the reduction of dye effluxed in presence of Vinblastine in CIPp and CIPm. Asterisk indicates a significative difference between the two cell lines in the same condition (Student’s t test p < 0.05)