Skip to main content

Table 1 Multidrug Resistance Direct Dye Efflux Activity in CIPp and CIPm

From: Doxorubicin treatment modulates chemoresistance and affects the cell cycle in two canine mammary tumour cell lines

 

CIPp

CIPm

 

Δ (N-P) MFI

Δ (P-V) MFI

Δ (N-P) MFI

Δ (P-V) MFI

15 min

43.87 ± 5.74

−33.34 ± 5.68*

41.55 ± 5.69

− 14.49 ± 5.38*

1 h

60.15 ± 5.81

−34.09 ± 5.33

59.75 ± 6.15

−29.15 ± 6.11

4 h

81.32 ± 5.25

−28.25 ± 6.01*

86.71 ± 5.13

−9.70 ± 5.08*

24 h

101.06 ± 4.98

− 13.58 ± 5.12*

101.47 ± 4.85

−3.49 ± 2.54*

  1. Differences (Δ) between median fluorescence intensity (MFI) values: ΔN-P (negative controls at 4 °C - positive controls at 37 °C) represents the amount of fluorescent dye effluxed at each time point, ΔP-V (positive controls at 37 °C - cells treated with Vinblastine at 37 °C) represents the reduction of dye effluxed in presence of Vinblastine in CIPp and CIPm. Asterisk indicates a significative difference between the two cell lines in the same condition (Student’s t test p < 0.05)
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us