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Table 5 Relative organ weights (g/100 g final bw) in dogs fed ethanamizuril on day 90 and 118 in subchronic toxicity study (Mean ± SD)

From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

  Day 90 Day 118
  High (n = 4) Middle (n = 4) Low(n = 4) Control (n = 4) High (n = 2) Control (n = 2)
male
 liver 48.1 ± 2.58 49.19 ± 1.77 50.26 ± 0.79 48.66 ± 2.15 50.02 ± 0.88 50.43 ± 0.31
 kidney 4.63 ± 0.15 4.9 ± 0.27 5.01 ± 0.65 4.81 ± 0.12 4.55 ± 0.12 4.56 ± 0.20
 spleen 4.19 ± 0.18 4.35 ± 0.22 4.31 ± 0.22 4.18 ± 0.28 4.17 ± 0.04 4.23 ± 0.10
 stomach and intestine 84.93 ± 4.51 85.17 ± 3.93 84.84 ± 8.21 85.33 ± 4.67 79.61 ± 0.35 79.37 ± 2.74
 lung 8.92 ± 0.22 9.12 ± 0.16 9.27 ± 0.45 9.08 ± 0.35 9.04 ± 0.13 9.22 ± 0.43
 heart 8.86 ± 0.47 9.06 ± 0.39 10.10 ± 0.15 8.90 ± 0.18 8.85 ± 0.24 8.83 ± 0.11
 brain 7.81 ± 0.23 8.16 ± 0.72 8.04 ± 0.25 7.97 ± 0.37 7.67 ± 0.12 7.60 ± 0.26
 adrenal gland 0.20 ± 0.02 0.21 ± 0.02 0.22 ± 0.02 0.22 ± 0.01 0.16 ± 0.01 0.16 ± 0.01
 testes 0.94 ± 0.09 0.93 ± 0.04 0.95 ± 0.04 0.94 ± 0.06 1.08 ± 0.06 1.01 ± 0.15
 epididymides 0.36 ± 0.03 0.38 ± 0.03 0.31 ± 0.01 0.3 ± 0.03 0.30 ± 0.02 0.30 ± 0
female
 liver 47.81 ± 1.49 48.65 ± 2.26 48.8 ± 1.43 48.15 ± 2.12 46.13 ± 0.95 47.26 ± 2.66
 kidney 4.88 ± 0.26 4.89 ± 0.19 5.15 ± 0.31 4.91 ± 0.20 4.88 ± 0.06 4.93 ± 0.39
 spleen 3.83 ± 0.10 3.9 ± 0.16 3.89 ± 0.19 3.86 ± 0.12 3.66 ± 0.05 3.78 ± 0.46
 stomach and intestine 89.78 ± 2.10 91.43 ± 3.18 88.14 ± 4.81 88.79 ± 4.65 86.06 ± 0.55 84.43 ± 2.90
 lung 9.81 ± 0.26 10.15 ± 0.19 10.16 ± 0.38 9.80 ± 0.41 9.67 ± 0.20 9.54 ± 0.32
 heart 9.47 ± 0.42 9.61 ± 0.28 9.14 ± 0.55 9.57 ± 0.55 9.34 ± 0.34 9.59 ± 0.57
 brain 8.17 ± 0.28 8.62 ± 0.19 8.34 ± 0.14 8.3 ± 0.31 8.14 ± 0.92 8.33 ± 0.38
 adrenal gland 0.19 ± 0.02 0.19 ± 0.01 0.17 ± 0.02 0.19 ± 0.01 0.18 ± 0 0.18 ± 0.01
 uterus 0.15 ± 0.02 0.15 ± 0.01 0.15 ± 0.01 0.15 ± 0.01 0.13 ± 0.02 0.13 ± 0.01
 ovaries 0.55 ± 0.03 0.57 ± 0.01 0.57 ± 0.02 0.56 ± 0.02 0.53 ± 0.04 0.54 ± 0
  1. Note: Control, Low, Middle and High refer to 0, 12, 60 and 300 mg/kg ethanamizuril dose. No test article-related effects were noted on the organ weights of the male and female animals treated with ethanamizuril compared to the control group in either males or females