From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril
Day 90 | Day 118 | |||||
---|---|---|---|---|---|---|
High (n = 4) | Middle (n = 4) | Low(n = 4) | Control (n = 4) | High (n = 2) | Control (n = 2) | |
male | ||||||
liver | 48.1 ± 2.58 | 49.19 ± 1.77 | 50.26 ± 0.79 | 48.66 ± 2.15 | 50.02 ± 0.88 | 50.43 ± 0.31 |
kidney | 4.63 ± 0.15 | 4.9 ± 0.27 | 5.01 ± 0.65 | 4.81 ± 0.12 | 4.55 ± 0.12 | 4.56 ± 0.20 |
spleen | 4.19 ± 0.18 | 4.35 ± 0.22 | 4.31 ± 0.22 | 4.18 ± 0.28 | 4.17 ± 0.04 | 4.23 ± 0.10 |
stomach and intestine | 84.93 ± 4.51 | 85.17 ± 3.93 | 84.84 ± 8.21 | 85.33 ± 4.67 | 79.61 ± 0.35 | 79.37 ± 2.74 |
lung | 8.92 ± 0.22 | 9.12 ± 0.16 | 9.27 ± 0.45 | 9.08 ± 0.35 | 9.04 ± 0.13 | 9.22 ± 0.43 |
heart | 8.86 ± 0.47 | 9.06 ± 0.39 | 10.10 ± 0.15 | 8.90 ± 0.18 | 8.85 ± 0.24 | 8.83 ± 0.11 |
brain | 7.81 ± 0.23 | 8.16 ± 0.72 | 8.04 ± 0.25 | 7.97 ± 0.37 | 7.67 ± 0.12 | 7.60 ± 0.26 |
adrenal gland | 0.20 ± 0.02 | 0.21 ± 0.02 | 0.22 ± 0.02 | 0.22 ± 0.01 | 0.16 ± 0.01 | 0.16 ± 0.01 |
testes | 0.94 ± 0.09 | 0.93 ± 0.04 | 0.95 ± 0.04 | 0.94 ± 0.06 | 1.08 ± 0.06 | 1.01 ± 0.15 |
epididymides | 0.36 ± 0.03 | 0.38 ± 0.03 | 0.31 ± 0.01 | 0.3 ± 0.03 | 0.30 ± 0.02 | 0.30 ± 0 |
female | ||||||
liver | 47.81 ± 1.49 | 48.65 ± 2.26 | 48.8 ± 1.43 | 48.15 ± 2.12 | 46.13 ± 0.95 | 47.26 ± 2.66 |
kidney | 4.88 ± 0.26 | 4.89 ± 0.19 | 5.15 ± 0.31 | 4.91 ± 0.20 | 4.88 ± 0.06 | 4.93 ± 0.39 |
spleen | 3.83 ± 0.10 | 3.9 ± 0.16 | 3.89 ± 0.19 | 3.86 ± 0.12 | 3.66 ± 0.05 | 3.78 ± 0.46 |
stomach and intestine | 89.78 ± 2.10 | 91.43 ± 3.18 | 88.14 ± 4.81 | 88.79 ± 4.65 | 86.06 ± 0.55 | 84.43 ± 2.90 |
lung | 9.81 ± 0.26 | 10.15 ± 0.19 | 10.16 ± 0.38 | 9.80 ± 0.41 | 9.67 ± 0.20 | 9.54 ± 0.32 |
heart | 9.47 ± 0.42 | 9.61 ± 0.28 | 9.14 ± 0.55 | 9.57 ± 0.55 | 9.34 ± 0.34 | 9.59 ± 0.57 |
brain | 8.17 ± 0.28 | 8.62 ± 0.19 | 8.34 ± 0.14 | 8.3 ± 0.31 | 8.14 ± 0.92 | 8.33 ± 0.38 |
adrenal gland | 0.19 ± 0.02 | 0.19 ± 0.01 | 0.17 ± 0.02 | 0.19 ± 0.01 | 0.18 ± 0 | 0.18 ± 0.01 |
uterus | 0.15 ± 0.02 | 0.15 ± 0.01 | 0.15 ± 0.01 | 0.15 ± 0.01 | 0.13 ± 0.02 | 0.13 ± 0.01 |
ovaries | 0.55 ± 0.03 | 0.57 ± 0.01 | 0.57 ± 0.02 | 0.56 ± 0.02 | 0.53 ± 0.04 | 0.54 ± 0 |