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Table 5 Relative organ weights (g/100 g final bw) in dogs fed ethanamizuril on day 90 and 118 in subchronic toxicity study (Mean ± SD)

From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

 

Day 90

Day 118

 

High (n = 4)

Middle (n = 4)

Low(n = 4)

Control (n = 4)

High (n = 2)

Control (n = 2)

male

 liver

48.1 ± 2.58

49.19 ± 1.77

50.26 ± 0.79

48.66 ± 2.15

50.02 ± 0.88

50.43 ± 0.31

 kidney

4.63 ± 0.15

4.9 ± 0.27

5.01 ± 0.65

4.81 ± 0.12

4.55 ± 0.12

4.56 ± 0.20

 spleen

4.19 ± 0.18

4.35 ± 0.22

4.31 ± 0.22

4.18 ± 0.28

4.17 ± 0.04

4.23 ± 0.10

 stomach and intestine

84.93 ± 4.51

85.17 ± 3.93

84.84 ± 8.21

85.33 ± 4.67

79.61 ± 0.35

79.37 ± 2.74

 lung

8.92 ± 0.22

9.12 ± 0.16

9.27 ± 0.45

9.08 ± 0.35

9.04 ± 0.13

9.22 ± 0.43

 heart

8.86 ± 0.47

9.06 ± 0.39

10.10 ± 0.15

8.90 ± 0.18

8.85 ± 0.24

8.83 ± 0.11

 brain

7.81 ± 0.23

8.16 ± 0.72

8.04 ± 0.25

7.97 ± 0.37

7.67 ± 0.12

7.60 ± 0.26

 adrenal gland

0.20 ± 0.02

0.21 ± 0.02

0.22 ± 0.02

0.22 ± 0.01

0.16 ± 0.01

0.16 ± 0.01

 testes

0.94 ± 0.09

0.93 ± 0.04

0.95 ± 0.04

0.94 ± 0.06

1.08 ± 0.06

1.01 ± 0.15

 epididymides

0.36 ± 0.03

0.38 ± 0.03

0.31 ± 0.01

0.3 ± 0.03

0.30 ± 0.02

0.30 ± 0

female

 liver

47.81 ± 1.49

48.65 ± 2.26

48.8 ± 1.43

48.15 ± 2.12

46.13 ± 0.95

47.26 ± 2.66

 kidney

4.88 ± 0.26

4.89 ± 0.19

5.15 ± 0.31

4.91 ± 0.20

4.88 ± 0.06

4.93 ± 0.39

 spleen

3.83 ± 0.10

3.9 ± 0.16

3.89 ± 0.19

3.86 ± 0.12

3.66 ± 0.05

3.78 ± 0.46

 stomach and intestine

89.78 ± 2.10

91.43 ± 3.18

88.14 ± 4.81

88.79 ± 4.65

86.06 ± 0.55

84.43 ± 2.90

 lung

9.81 ± 0.26

10.15 ± 0.19

10.16 ± 0.38

9.80 ± 0.41

9.67 ± 0.20

9.54 ± 0.32

 heart

9.47 ± 0.42

9.61 ± 0.28

9.14 ± 0.55

9.57 ± 0.55

9.34 ± 0.34

9.59 ± 0.57

 brain

8.17 ± 0.28

8.62 ± 0.19

8.34 ± 0.14

8.3 ± 0.31

8.14 ± 0.92

8.33 ± 0.38

 adrenal gland

0.19 ± 0.02

0.19 ± 0.01

0.17 ± 0.02

0.19 ± 0.01

0.18 ± 0

0.18 ± 0.01

 uterus

0.15 ± 0.02

0.15 ± 0.01

0.15 ± 0.01

0.15 ± 0.01

0.13 ± 0.02

0.13 ± 0.01

 ovaries

0.55 ± 0.03

0.57 ± 0.01

0.57 ± 0.02

0.56 ± 0.02

0.53 ± 0.04

0.54 ± 0

  1. Note: Control, Low, Middle and High refer to 0, 12, 60 and 300 mg/kg ethanamizuril dose. No test article-related effects were noted on the organ weights of the male and female animals treated with ethanamizuril compared to the control group in either males or females