Fig. 3

Effects of ivermectin cream on cutaneous wound tissue levels of MPO and hydroxyproline. Sprague-Dawley rats were anaesthetised and excision wounds created as described in the methods. Animals were sacrificed on either day 7 or day 21 post-wounding. The levels of myeloperoxidase on day 7 as well as levels of hydroxyproline on day 7 and day 21 were measured and presented as mean ± SEM. The statistical analysis for MPO levels was by One-Way ANOVA. * means p < 0.05, ** means p < 0.01,*** means p < 0.001 for treated groups when compared to the vehicle (naïve) control group. The statistical analysis for hydroxyproline was by Two-Way ANOVA followed by Bonferroni's post hoc test. * means p < 0.05,** means p < 0.01 when compared to the corresponding day control levels whilst # means p < 0.05, ## means p < 0.01, #### means p < 0.0001 when comparing levels on day 7 to day 21 within a group