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Table 7 Gastrointestinal scores (mean ± SD), following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Time (h)

saline

0.25 mg/kg

0.5 mg/kg

1.0 mg/kg

Baseline

2.4 ± 1.2

2.4 ± 1.4

2.5 ± 1.3

3.0 ± 1.4

0.5

1.9 ± 0.4

2.6 ± 0.5

2.6 ± 1.1

2.5 ± 1.4

0.75

2.4 ± 0.9

2.3 ± 1.0

2.6 ± 0.5

2.0 ± 0.9*

1

2.5 ± 1.1

2.6 ± 0.5

2.9 ± 1.4

2.1 ± 0.4*

2

2.3 ± 0.9

2.6 ± 1.0

2.5 ± 0.8

2.1 ± 0.8*

4

1.9 ± 0.6

2.6 ± 1.0

2.4 ± 0.9

2.5 ± 1.4

6

2.3 ± 0.9

2.1 ± 0.9

2.4 ± 1.3

2.6 ± 0.5

8

---

3.0 ± 1.2

3.1 ± 1.6

1.9 ± 0.6*

24

---

2.7 ± 1.3

2.7 ± 1.1

2.8 ± 1.2

  1. ---, not assessed; *, indicates a significant difference (p < .05) relative to baseline