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Table 7 Gastrointestinal scores (mean ± SD), following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Time (h) saline 0.25 mg/kg 0.5 mg/kg 1.0 mg/kg
Baseline 2.4 ± 1.2 2.4 ± 1.4 2.5 ± 1.3 3.0 ± 1.4
0.5 1.9 ± 0.4 2.6 ± 0.5 2.6 ± 1.1 2.5 ± 1.4
0.75 2.4 ± 0.9 2.3 ± 1.0 2.6 ± 0.5 2.0 ± 0.9*
1 2.5 ± 1.1 2.6 ± 0.5 2.9 ± 1.4 2.1 ± 0.4*
2 2.3 ± 0.9 2.6 ± 1.0 2.5 ± 0.8 2.1 ± 0.8*
4 1.9 ± 0.6 2.6 ± 1.0 2.4 ± 0.9 2.5 ± 1.4
6 2.3 ± 0.9 2.1 ± 0.9 2.4 ± 1.3 2.6 ± 0.5
8 --- 3.0 ± 1.2 3.1 ± 1.6 1.9 ± 0.6*
24 --- 2.7 ± 1.3 2.7 ± 1.1 2.8 ± 1.2
  1. ---, not assessed; *, indicates a significant difference (p < .05) relative to baseline