Table 5 Heart rate (mean ± SD), following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

0

33.5 ± 2.8

34.0 ± 2.8

34.0 ± 5.1

34.4 ± 2.3

0.03

33.9 ± 2.4

39.0 ± 8.1

54.3 ± 17.9^*

90.3 ± 36.4^*

0.08

34.9 ± 2.5

34.7 ± 3.9

37.6 ± 5.2

50.1 ± 9.3^*

0.13

35.1 ± 3.0

36.4 ± 4.2

38.5 ± 9.5

50.6 ± 14.0^*

0.17

35.4 ± 3.2

35.7 ± 3.1

37.1 ± 6.5

44.1 ± 5.2^*

0.20

34.6 ± 3.1

34.3 ± 1.9

39.3 ± 9.9

40.1 ± 3.4

0.25

35.4 ± 2.8

35.3 ± 4.5

35.9 ± 3.1

44.1 ± 12.9^*

0.33

34.3 ± 2.1

34.7 ± 3.9

37.9 ± 3.0

41.1 ± 6.1

0.5

34.7 ± 3.2

35.4 ± 2.6

35.8 ± 3.5

37.0 ± 1.4

0.75

33.7 ± 3.0

34.9 ± 2.2

38.6 ± 8.2

36.9 ± 2.5

1

33.6 ± 3.6

33.4 ± 6.4

35.3 ± 2.0

36.8 ± 3.4

1.25

33.7 ± 2.4

36.1 ± 3.3

36.0 ± 3.9

35.9 ± 3.8

1.5

36.9 ± 3.6

35.3 ± 2.7

38.4 ± 6.0

39.6 ± 10.5

2

32.3 ± 4.4

32.7 ± 4.2

34.5 ± 3.7

34.0 ± 4.6

2.5

31.7 ± 4.0

36.0 ± 2.5

35.1 ± 3.1

36.5 ± 4.0

3

36.8 ± 5.4

33.4 ± 5.2

33.1 ± 3.1

32.4 ± 3.9

4

34.8 ± 8.7

34.6 ± 3.5

32.5 ± 2.8

32.0 ± 2.3

5

31.1 ± 4.6

37.9 ± 21.5

35.5 ± 6.6

34.9 ± 5.1

6

31.7 ± 2.7

31.0 ± 3.1

32.9 ± 3.4

31.4 ± 3.2