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Table 5 Heart rate (mean ± SD), following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Time (h) Saline 0.25 mg/kg 0.5 mg/kg 1.0 mg/kg
0 33.5 ± 2.8 34.0 ± 2.8 34.0 ± 5.1 34.4 ± 2.3
0.03 33.9 ± 2.4 39.0 ± 8.1 54.3 ± 17.9* 90.3 ± 36.4*
0.08 34.9 ± 2.5 34.7 ± 3.9 37.6 ± 5.2 50.1 ± 9.3*
0.13 35.1 ± 3.0 36.4 ± 4.2 38.5 ± 9.5 50.6 ± 14.0*
0.17 35.4 ± 3.2 35.7 ± 3.1 37.1 ± 6.5 44.1 ± 5.2*
0.20 34.6 ± 3.1 34.3 ± 1.9 39.3 ± 9.9 40.1 ± 3.4
0.25 35.4 ± 2.8 35.3 ± 4.5 35.9 ± 3.1 44.1 ± 12.9*
0.33 34.3 ± 2.1 34.7 ± 3.9 37.9 ± 3.0 41.1 ± 6.1
0.5 34.7 ± 3.2 35.4 ± 2.6 35.8 ± 3.5 37.0 ± 1.4
0.75 33.7 ± 3.0 34.9 ± 2.2 38.6 ± 8.2 36.9 ± 2.5
1 33.6 ± 3.6 33.4 ± 6.4 35.3 ± 2.0 36.8 ± 3.4
1.25 33.7 ± 2.4 36.1 ± 3.3 36.0 ± 3.9 35.9 ± 3.8
1.5 36.9 ± 3.6 35.3 ± 2.7 38.4 ± 6.0 39.6 ± 10.5
2 32.3 ± 4.4 32.7 ± 4.2 34.5 ± 3.7 34.0 ± 4.6
2.5 31.7 ± 4.0 36.0 ± 2.5 35.1 ± 3.1 36.5 ± 4.0
3 36.8 ± 5.4 33.4 ± 5.2 33.1 ± 3.1 32.4 ± 3.9
4 34.8 ± 8.7 34.6 ± 3.5 32.5 ± 2.8 32.0 ± 2.3
5 31.1 ± 4.6 37.9 ± 21.5 35.5 ± 6.6 34.9 ± 5.1
6 31.7 ± 2.7 31.0 ± 3.1 32.9 ± 3.4 31.4 ± 3.2
  1. *, indicates a significant difference (p < .05) relative to baseline