Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel

BMC Veterinary Research

Table 4 Gene expression changes associated with calcium signalling and hepatic fibrosis/hepatic stellate cell activation canonical pathways

Datasets	Gene name
Calcium Signalling
CKCS vs Normal	*ACTA1*, ACTA2, AKAP5, *ATP2A2, CASQ, GRIN2A, GRIA3,* HDAC9, *MYH7, MYH7B*, MYH1, *MYL4, NFATC1, RCAN2, RYR2, SLC8B1, TNNI3,* TPM2, *TRDN*
CKCS vs non-CKCS	*ACTA1, ATP2A2, CACNA1G, CACNA1H, CASQ2, MYH7, RCAN2, SLC8B1, TNNI3, TRDN*
All diseased vs Normal	ACTA2, HDAC9, MYH11, TPM2, *TRPC5*
Hepatic fibrosis/hepatic stellate cell activation
CKCS vs Normal	ACTA2, CCL5, *COL6A3, EDNRA*, IL1RL1, *KDR, LAMA1, MYH7*, MYH11, *MYH7B, MYL4, NGFR, PDGFR*, SERPINE1,
All diseased vs Normal	ACTA2, *COL11A2,* MYH11, SERPINE1

ISSN: 1746-6148