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Table 3 mRNA levels of factors involved in ECM remodeling

From: Interstitial changes after reperfused myocardial infarction in swine: morphometric and genetic analysis

 

CONTROL

ISCHEMIA WITHOUT REPERFUSION

1-WEEK REPERFUSION

1-MONTH REPERFUSION

NECROTIC

SALVAGED

NECROTIC

SALVAGED

NECROTIC

SALVAGED

TNF-α

1.10 ± 0.54

6.52 ± 4.44

6.26 ± 3.18

20.59 ± 11.10**

7.54 ± 6.17

60.98 ± 21.55**

11.30 ± 10.35

BSG

1.01 ± 0.18

1.35 ± 0.25

1.31 ± 0.22

0.38 ± 0.07*

0.27 ± 0.22*

0.74 ± 0.47

0.52 ± 0.50

TGF-β

1.06 ± 0.42

2.06 ± 0.24

1.81 ± 0.32

2.79 ± 1.49

0.48 ± 0.22

16.62 ± 12.04**

0.65 ± 0.79

CTGF

1.24 ± 0.77

7.40 ± 1.27**

3.01 ± 1.00*

3.10 ± 2.66

0.28 ± 0.09

28.25 ± 13.64**

0.98 ± 0.32

MMP2

1.05 ± 0.13

1.98 ± 0.65

3.26 ± 1.30

27.08 ± 7.5**

3.95 ± 2.28

15.97 ± 4.24**

4.09 ± 2.26

MMP9

1.02 ± 0.22

5.79 ± 7.64

4.62 ± 4.08

95.98 ± 69.45*

7.05 ± 6.65

272.31 ± 140.89**

5.95 ± 6.70

MMP14

1.03 ± 0.22

2.78 ± 0.93

2.18 ± 0.71**

2.95 ± 2.54

0.28 ± 0.22*

6.21 ± 2.79*

0.15 ± 0.07*

MMP15

1.03 ± 0.30

2.12 ± 1.02

1.82 ± 0.90

1.13 ± 1.07

0.41 ± .13

1.13 ± 1.07

0.62 ± 0.73

MMP16

1.05 ± 0.35

2.43 ± 1.14

2.04 ± 0.58

1.15 ± 0.68

0.58 ± 0.32

6.39 ± 2.70*

1.55 ± 0.87

TIMP1

1.02 ± 0.23

6.50 ± 2.92*

5.64 ± 3.19*

27.14 ± 17.37**

1.92 ± 1.32

30.92 ± 18.14**

1.15 ± 0.75

TIMP2

1.00 ± 0.08

3.08 ± 0.98**

2.60 ± 0.85**

4.19 ± 1.77*

0.99 ± 0.86

32.50 ± 20.41**

0.89 ± 0.47

TIMP3

0.96 ± 0.15

2.82 ± 1.45*

1.77 ± 0.47

1.06 ± 0.88

0.58 ± 0.29

4.83 ± 2.80*

0.81 ± 0.40

TIMP4

1.29 ± 0.35

1.45 ± 0.59

1.51 ± 0.30

1.32 ± 0.45

0.37 ± 0.16**

1.14 ± 0.60

0.36 ± 0.21**

COL1A1

1.02 ± 0.25

3.99 ± 2.30

2.65 ± 1.54

10.58 ± 4.81

2.37 ± 1.07

45.71 ± 29.07**

2.17 ± 2.15

COL3A1

1.05 ± 0.37

2.86 ± 1.83

1.87 ± 0.84

4.39 ± 2.00

1.17 ± 0.81

18.03 ± 12.52*

1.14 ± 0.62

FN1

1.03 ± 0.52

3.76 ± 2.35

2.31 ± 0.75

17.84 ± 8.55**

1.75 ± 1.24

106.10 ± 43.39**

2.20 ± 2.25

LAMB2

1.08 ± 0.32

2.07 ± 0.97

1.97 ± 0.64

25.84 ± 8.60**

2.15 ± 0.51

54.04 ± 23.06**

2.09 ± 0.87

  1. Abbreviations: BSG Basigin; COL Collagen; CTGF Connective tissue growth factor; ECM Extracellular matrix; FN Fibronectin; LAMB: Laminin; MMP Metalloproteinases; TIMP Tissue inhibitors of metalloproteinases: TGF Transforming growth factor; TNF Tumor necrosis factor
  2. Data were expressed as mean ± SD (n ≥ 5) and were analysed by one-way ANOVA followed by Bonferroni test. *P < 0.05, **P < 0.01 vs. control
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BMC Veterinary Research

ISSN: 1746-6148

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