| |
CONTROL
|
ISCHEMIA WITHOUT REPERFUSION
|
1-WEEK REPERFUSION
|
1-MONTH REPERFUSION
|
|---|
|
NECROTIC
|
SALVAGED
|
NECROTIC
|
SALVAGED
|
NECROTIC
|
SALVAGED
|
|---|
|
TNF-α
|
1.10 ± 0.54
|
6.52 ± 4.44
|
6.26 ± 3.18
|
20.59 ± 11.10**
|
7.54 ± 6.17
|
60.98 ± 21.55**
|
11.30 ± 10.35
|
|
BSG
|
1.01 ± 0.18
|
1.35 ± 0.25
|
1.31 ± 0.22
|
0.38 ± 0.07*
|
0.27 ± 0.22*
|
0.74 ± 0.47
|
0.52 ± 0.50
|
|
TGF-β
|
1.06 ± 0.42
|
2.06 ± 0.24
|
1.81 ± 0.32
|
2.79 ± 1.49
|
0.48 ± 0.22
|
16.62 ± 12.04**
|
0.65 ± 0.79
|
|
CTGF
|
1.24 ± 0.77
|
7.40 ± 1.27**
|
3.01 ± 1.00*
|
3.10 ± 2.66
|
0.28 ± 0.09
|
28.25 ± 13.64**
|
0.98 ± 0.32
|
|
MMP2
|
1.05 ± 0.13
|
1.98 ± 0.65
|
3.26 ± 1.30
|
27.08 ± 7.5**
|
3.95 ± 2.28
|
15.97 ± 4.24**
|
4.09 ± 2.26
|
|
MMP9
|
1.02 ± 0.22
|
5.79 ± 7.64
|
4.62 ± 4.08
|
95.98 ± 69.45*
|
7.05 ± 6.65
|
272.31 ± 140.89**
|
5.95 ± 6.70
|
|
MMP14
|
1.03 ± 0.22
|
2.78 ± 0.93
|
2.18 ± 0.71**
|
2.95 ± 2.54
|
0.28 ± 0.22*
|
6.21 ± 2.79*
|
0.15 ± 0.07*
|
|
MMP15
|
1.03 ± 0.30
|
2.12 ± 1.02
|
1.82 ± 0.90
|
1.13 ± 1.07
|
0.41 ± .13
|
1.13 ± 1.07
|
0.62 ± 0.73
|
|
MMP16
|
1.05 ± 0.35
|
2.43 ± 1.14
|
2.04 ± 0.58
|
1.15 ± 0.68
|
0.58 ± 0.32
|
6.39 ± 2.70*
|
1.55 ± 0.87
|
|
TIMP1
|
1.02 ± 0.23
|
6.50 ± 2.92*
|
5.64 ± 3.19*
|
27.14 ± 17.37**
|
1.92 ± 1.32
|
30.92 ± 18.14**
|
1.15 ± 0.75
|
|
TIMP2
|
1.00 ± 0.08
|
3.08 ± 0.98**
|
2.60 ± 0.85**
|
4.19 ± 1.77*
|
0.99 ± 0.86
|
32.50 ± 20.41**
|
0.89 ± 0.47
|
|
TIMP3
|
0.96 ± 0.15
|
2.82 ± 1.45*
|
1.77 ± 0.47
|
1.06 ± 0.88
|
0.58 ± 0.29
|
4.83 ± 2.80*
|
0.81 ± 0.40
|
|
TIMP4
|
1.29 ± 0.35
|
1.45 ± 0.59
|
1.51 ± 0.30
|
1.32 ± 0.45
|
0.37 ± 0.16**
|
1.14 ± 0.60
|
0.36 ± 0.21**
|
|
COL1A1
|
1.02 ± 0.25
|
3.99 ± 2.30
|
2.65 ± 1.54
|
10.58 ± 4.81
|
2.37 ± 1.07
|
45.71 ± 29.07**
|
2.17 ± 2.15
|
|
COL3A1
|
1.05 ± 0.37
|
2.86 ± 1.83
|
1.87 ± 0.84
|
4.39 ± 2.00
|
1.17 ± 0.81
|
18.03 ± 12.52*
|
1.14 ± 0.62
|
|
FN1
|
1.03 ± 0.52
|
3.76 ± 2.35
|
2.31 ± 0.75
|
17.84 ± 8.55**
|
1.75 ± 1.24
|
106.10 ± 43.39**
|
2.20 ± 2.25
|
|
LAMB2
|
1.08 ± 0.32
|
2.07 ± 0.97
|
1.97 ± 0.64
|
25.84 ± 8.60**
|
2.15 ± 0.51
|
54.04 ± 23.06**
|
2.09 ± 0.87
|
- Abbreviations: BSG Basigin; COL Collagen; CTGF Connective tissue growth factor; ECM Extracellular matrix; FN Fibronectin; LAMB: Laminin; MMP Metalloproteinases; TIMP Tissue inhibitors of metalloproteinases: TGF Transforming growth factor; TNF Tumor necrosis factor
- Data were expressed as mean ± SD (n ≥ 5) and were analysed by one-way ANOVA followed by Bonferroni test. *P < 0.05, **P < 0.01 vs. control
