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Table 3 mRNA levels of factors involved in ECM remodeling

From: Interstitial changes after reperfused myocardial infarction in swine: morphometric and genetic analysis

  CONTROL ISCHEMIA WITHOUT REPERFUSION 1-WEEK REPERFUSION 1-MONTH REPERFUSION
NECROTIC SALVAGED NECROTIC SALVAGED NECROTIC SALVAGED
TNF-α 1.10 ± 0.54 6.52 ± 4.44 6.26 ± 3.18 20.59 ± 11.10** 7.54 ± 6.17 60.98 ± 21.55** 11.30 ± 10.35
BSG 1.01 ± 0.18 1.35 ± 0.25 1.31 ± 0.22 0.38 ± 0.07* 0.27 ± 0.22* 0.74 ± 0.47 0.52 ± 0.50
TGF-β 1.06 ± 0.42 2.06 ± 0.24 1.81 ± 0.32 2.79 ± 1.49 0.48 ± 0.22 16.62 ± 12.04** 0.65 ± 0.79
CTGF 1.24 ± 0.77 7.40 ± 1.27** 3.01 ± 1.00* 3.10 ± 2.66 0.28 ± 0.09 28.25 ± 13.64** 0.98 ± 0.32
MMP2 1.05 ± 0.13 1.98 ± 0.65 3.26 ± 1.30 27.08 ± 7.5** 3.95 ± 2.28 15.97 ± 4.24** 4.09 ± 2.26
MMP9 1.02 ± 0.22 5.79 ± 7.64 4.62 ± 4.08 95.98 ± 69.45* 7.05 ± 6.65 272.31 ± 140.89** 5.95 ± 6.70
MMP14 1.03 ± 0.22 2.78 ± 0.93 2.18 ± 0.71** 2.95 ± 2.54 0.28 ± 0.22* 6.21 ± 2.79* 0.15 ± 0.07*
MMP15 1.03 ± 0.30 2.12 ± 1.02 1.82 ± 0.90 1.13 ± 1.07 0.41 ± .13 1.13 ± 1.07 0.62 ± 0.73
MMP16 1.05 ± 0.35 2.43 ± 1.14 2.04 ± 0.58 1.15 ± 0.68 0.58 ± 0.32 6.39 ± 2.70* 1.55 ± 0.87
TIMP1 1.02 ± 0.23 6.50 ± 2.92* 5.64 ± 3.19* 27.14 ± 17.37** 1.92 ± 1.32 30.92 ± 18.14** 1.15 ± 0.75
TIMP2 1.00 ± 0.08 3.08 ± 0.98** 2.60 ± 0.85** 4.19 ± 1.77* 0.99 ± 0.86 32.50 ± 20.41** 0.89 ± 0.47
TIMP3 0.96 ± 0.15 2.82 ± 1.45* 1.77 ± 0.47 1.06 ± 0.88 0.58 ± 0.29 4.83 ± 2.80* 0.81 ± 0.40
TIMP4 1.29 ± 0.35 1.45 ± 0.59 1.51 ± 0.30 1.32 ± 0.45 0.37 ± 0.16** 1.14 ± 0.60 0.36 ± 0.21**
COL1A1 1.02 ± 0.25 3.99 ± 2.30 2.65 ± 1.54 10.58 ± 4.81 2.37 ± 1.07 45.71 ± 29.07** 2.17 ± 2.15
COL3A1 1.05 ± 0.37 2.86 ± 1.83 1.87 ± 0.84 4.39 ± 2.00 1.17 ± 0.81 18.03 ± 12.52* 1.14 ± 0.62
FN1 1.03 ± 0.52 3.76 ± 2.35 2.31 ± 0.75 17.84 ± 8.55** 1.75 ± 1.24 106.10 ± 43.39** 2.20 ± 2.25
LAMB2 1.08 ± 0.32 2.07 ± 0.97 1.97 ± 0.64 25.84 ± 8.60** 2.15 ± 0.51 54.04 ± 23.06** 2.09 ± 0.87
  1. Abbreviations: BSG Basigin; COL Collagen; CTGF Connective tissue growth factor; ECM Extracellular matrix; FN Fibronectin; LAMB: Laminin; MMP Metalloproteinases; TIMP Tissue inhibitors of metalloproteinases: TGF Transforming growth factor; TNF Tumor necrosis factor
  2. Data were expressed as mean ± SD (n ≥ 5) and were analysed by one-way ANOVA followed by Bonferroni test. *P < 0.05, **P < 0.01 vs. control