Fig. 3

Immunohistochemical expression of proliferative and cell cycle regulatory markers. a Hemangioma. Presence of few Ki-67-positive tumour nuclei. Inset: Positive nuclear expression (arrows). b Well-differentiated hemangiosarcoma. Numerous Ki-67-positive neoplastic nuclei. c Hemangioma. No labeling for p53. d Well-differentiated hemangiosarcoma. Note a high number of neoplastic cells showing strong nuclear expression for p53. e Hemangioma. No labeling for pp53 Ser³⁹². f Moderately differentiated hemangiosarcoma. Strong nuclear pp53 Ser³⁹² reaction in numerous neoplastic cells. Peroxidase-DAB revelation system, Harris Haematoxylin counterstain. 200x