Parameter | Unit | IV (n = 8) | IM (n = 8) | SC (n = 6)* |
---|---|---|---|---|
AUC 0-t | ng/mL*h | 14.49 (12.86–16.11) | 9.32 (6.53–12.11) | 5.79 (4.26–7.32) |
AUC 0-∞ | ng/mL*h | 15.77 (13.87–17.67) | 12.41 (10.39–14.43) | 16.45 (8.00–24.90) |
C0 or Cmax | ng/mL | 35.92 (14.42–57.43) | 6.24 (2.78–9.70) | 1.37 (0.89–1.85) |
F | % | – | 62.6 | 40 |
Tmax | h | – | 0.14 (0.01–0.26) | 0.33 (0.20–0.47) |
λ z | 1/h | 0.19 (0.17–0.21) | 0.14 (0.10–0.18) | 0.04 (0.02–0.06) |
t1/2 | h | 3.69 (3.25–4.14) | 5.66 (2.82–8.50) | 21.95 (12.03–31.87) |
MRT0-∞ | h | 3.59 (3.06–4.12) | 7.37 (3.00–11.73) | 30.02 (15.77–44.27) |
Cl or Cl/F | L/h/kg | 1.29 (1.14–1.45) | 1.65 (1.40–1.91) | 1.40 (0.91–1.88) |
Vz or Vz/F | L/kg | 6.82 (6.06–7.58) | 14.16 (4.50–23.81) | 40.13 (26.27–53.98) |
Vss | L/kg | 4.59 (3.98–5.19) | NC | NC |