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Table 1 PK parameters of gamithromycin in serum from six piglets following single IV, IM and SC administrations at 6.0 mg/kg (n = 6)

From: Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets

PK parametersUnitIV routeIM routeSC route
Tmaxh0.36 ± 0.241.59 ± 1.40
Cmaxmg/L0.99 ± 0.290.61 ± 0.14
T1/2h25.4 ± 2.9029.4 ± 3.7129.0 ± 3.44
AUClastmg·h/L6.32 ± 1.246.28 ± 1.565.45 ± 1.56
AUC0-∞mg·h/L6.56 ± 1.316.63 ± 1.895.72 ± 1.67
ClL/kg/h0.92 ± 0.19
Cl/FL/kg/h0.91 ± 0.261.05 ± 0.30
VssL/kg18.1 ± 3.20
F%101.187.2
  1. Tmax time to reach peak concentration (Cmax), T1/2 terminal half-life, AUC the area under the concentration-time curve from 0 to the last sampling point (AUClast) or from 0 to ∞ (AUC0-∞), Cl body clearance, Cl/F clearance scaled by bioavailability, Vss volume of distribution at steady-state, F bioavailability
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