Table 1 PK parameters of gamithromycin in serum from six piglets following single IV, IM and SC administrations at 6.0 mg/kg (n = 6)

T_max

h

–

0.36 ± 0.24

1.59 ± 1.40

C_max

mg/L

–

0.99 ± 0.29

0.61 ± 0.14

T_1/2

h

25.4 ± 2.90

29.4 ± 3.71

29.0 ± 3.44

AUC_last

mg·h/L

6.32 ± 1.24

6.28 ± 1.56

5.45 ± 1.56

AUC_0-∞

mg·h/L

6.56 ± 1.31

6.63 ± 1.89

5.72 ± 1.67

Cl

L/kg/h

0.92 ± 0.19

–

–

Cl/F

L/kg/h

–

0.91 ± 0.26

1.05 ± 0.30

V_ss

L/kg

18.1 ± 3.20

–

–

F

%

–

101.1

87.2