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Table 3 Variables assessed to calculate the aggregate tissue irritation score (ATIS)

From: Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9–1 using a subcuticular technique in pigs

VariableScoreaWeighting factorMaximum score
Extravascular neutrophils0–5− 6− 30
Macrophages0–5− 1− 5
Multinucleated giant cells0–5− 2− 10
Lymphocytes0–5− 2− 10
Fibroblasts0–5− 1− 5
Overall severity of inflammatory response to suture material (total estimated cell number)0–5− 3− 15
Bacterial colonies0–3− 3− 9
ATIS  − 84
  1. aThe absence of the variable was scored as zero, and its presence was semi-quantitatively scored in an order increasing from 1 to 3 (presence of bacterial colonies) or 1 to 5 (all other variables)