Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9–1 using a subcuticular technique in pigs

Table 3 Variables assessed to calculate the aggregate tissue irritation score (ATIS)

Variable	Score^a	Weighting factor	Maximum score
Extravascular neutrophils	0–5	− 6	− 30
Macrophages	0–5	− 1	− 5
Multinucleated giant cells	0–5	− 2	− 10
Lymphocytes	0–5	− 2	− 10
Fibroblasts	0–5	− 1	− 5
Overall severity of inflammatory response to suture material (total estimated cell number)	0–5	− 3	− 15
Bacterial colonies	0–3	− 3	− 9
ATIS			− 84

^aThe absence of the variable was scored as zero, and its presence was semi-quantitatively scored in an order increasing from 1 to 3 (presence of bacterial colonies) or 1 to 5 (all other variables)

ISSN: 1746-6148