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Table 1 Haemodynamic parameters in control (C) and methylene blue groups (MB5 and MB20)

From: Assessment of effects of methylene blue on intestinal ischemia and reperfusion in a rabbit model: hemodynamic, histological and immunohistochemical study

VariablesGroupBasalineIschemiaR60R120R240R360Reperfusion
HR (bpm)C207 ± 32 a175 ± 41a173 ± 31178 ± 27184 ± 28190 ± 28179 ± 29♯,
MB5200 ± 18 a182 ± 16 a,c197 ± 28209 ± 25213 ± 24216 ± 20207 ± 26 c♯,†
MB20199 ± 23 a176 ± 23 a,c183 ± 26198 ± 29194 ± 37200 ± 34190 ± 30 c,†
RR (rpm)C35 ± 932 ± 836 ± 123283510351034 ± 10♯,
MB537 ± 1035 ± 5 c41 ± 84364810461043 ± 9 c
MB2034 ± 733 ± 8 c35 ± 840134212451440 ± 12 c
MAP (mmHg)C64 ± 6 a,b41 ± 13 a41 ± 1142 ± 1141 ± 1038 ± 1140 ± 10 b♯,
MB566 ± 15 a46 ± 13 a,c65 ± 1558 ± 1356 ± 1355 ± 1259 ± 14 c♯,†
MB2061 ± 14 ª,b47 ± 10 a50 ± 945 ± 945 ± 746 ± 847 ± 9b,†
SAP (mmHg)C84 ± 12 a,b52 ± 15 a56 ± 1459 ± 1256 ± 1252 ± 1356 ± 13 b♯,
MB589 ± 23 a60 ± 18 a,c95 ± 2184 ± 1579 ± 1475 ± 1485 ± 18 c♯,†
MB2083 ± 19 a62 ± 17 a78 ± 1770 ± 1866 ± 1469 ± 1472 ± 17,†
DAP (mmHg)C51 ± 6 a,b35 ± 11 a32 ± 933 ± 1033 ± 830 ± 931 ± 9 b♯,
MB552 ± 14 a39 ± 11 a,c49 ± 1245 ± 1142 ± 1042 ± 1045 ± 11 c♯,†
MB2045 ± 13 a,b37 ± 10 a35 ± 933 ± 735 ± 637 ± 936 ± 6 b†,
CI (mL/min/kg)C177 ± 52 a,b115 ± 53 a124 ± 49126 ± 28110 ± 16127 ± 27123 ± 39 b♯,
MB5190 ± 33 a103 ± 29 a,c172 ± 47191 ± 53186 ± 51183 ± 45182 ± 50 c
MB20189 ± 39 a111 ± 32 a,c185 ± 68168 ± 56165 ± 60177 ± 73175 ± 63 c
dPmx (mmHg/s)C888 ± 363 a,b488 ± 161 a628 ± 266605 ± 274535 ± 158450 ± 128584 ± 250 b♯,
MB5941 ± 193 a558 ± 237 a,c1244 ± 3571072 ± 253930 ± 256918 ± 1941080 ± 314 c
MB20931 ± 276 a577 ± 140 a,c1218 ± 403916 ± 463874 ± 3901017 ± 4051031 ± 442 c
SVI (mL/beat/kg)C0.88 ± 0.31 a0.68 ± 0.30 a0.73 ± 0.320.71 ± 0.180.55 ± 0.170.62 ± 0.160.69 ± 0.26♯,
MB50.95 ± 0.15 a0.54 ± 0.13 a,c0.93 ± 0.340.98 ± 0.340.92 ± 0.300.89 ± 0.320.94 ± 0.32 c
MB200.98 ± 0.26 a0.65 ± 0.20 a,c1.00 ± 0.360.83 ± 0.200.82 ± 0.220.89 ± 0.250.91 ± 0.30 c
SVRI (mmHg/mL/min/kg)C0.37 ± 0.10 a0.40 ± 0.18 a,c0.33 ± 0.130.30 ± 0.080.32 ± 0.070.25 ± 0.10.30 ± 0.10 c
MB50.33 ± 0.09 a0.44 ± 0.15 a,c0.34 ± 0.070.32 ± 0.060.30 ± 0.080.31 ± 0.090.33 ± 0.11 c♯,†
MB200.31 ± 0.11 a0.42 ± 0.13 a,c0.26 ± 0.100.27 ± 0.060.32 ± 0.070.30 ± 0.190.28 ± 0.09 c
CaO2 (mL/dL)C16.4 ± 1.2 a,b14.2 ± 1.7 a15.1 ± 1.614.8 ± 1.413.8 ± 0.912.1 ± 1.914.8 ± 2.1 b 
MB515.7 ± 1.8 a,b14.7 ± 1.5 a15.6 ± 1.514.8 ± 1.513.9 ± 1.713.5 ± 1.914.4 ± 2.1 b
MB2016.1 ± 1.1 a,b14.1 ± 2.5 a13.8 ± 2.613.1 ± 2.212.7 ± 2.512.3 ± 2.713.3 ± 2.6 b
DO2 (mL/min/kg)C29.3 ± 8.3 a,b15.9 ± 8.8 a19.2 ± 5.916.2 ± 4.214.7 ± 4.114.8 ± 3.016.4 ± 4.6 b♯,
MB529.5 ± 7.9 a15.7 ± 7.1 a,c25.7 ± 6.427.0 ± 4.924.8 ± 6.720.0 ± 7.424.4 ± 6.3 c
MB2030.1 ± 8.6 a15.6 ± 4.5 a,c28.5 ± 13.924.5 ± 5.621.9 ± 8.219.7 ± 8.523.6 ± 10.5 c
VVS (%)C12 ± 2 a,b22 ± 7 a19 ± 521 ± 621 ± 524 ± 720 ± 5 b
MB510 ± 3 a19 ± 6 a,c15 ± 415 ± 613 ± 512 ± 314 ± 5 c♯,†
MB2012 ± 3 a,b19 ± 5 a17 ± 617 ± 819 ± 919 ± 1018 ± 8 b
Lactate (mmol/L)C2.8 ± 1.1 a,b5.6 ± 1.8 a7.7 ± 2.06.6 ± 2.46.0 ± 1.75.7 ± 1.96.9 ± 2.6 b
MB52.4 ± 1.0 a,b4.9 ± 1.3 a,5.5 ± 1.24.7 ± 1.74.3 ± 1.44.5 ± 1.44.8 ± 1.2 b♯,†
MB202.8 ± 0.9 a,b5.2 ± 1.9a6.3 ± 2.16.4 ± 3.16.0 ± 3.05.5 ± 2.46.1 ± 2.4 b
Hemoglobine (gr/dL)C12.3 ± 1.1 a,b10.4 ± 1.4 a10.9 ± 1.610.7 ± 1.59.2 ± 1.68.9 ± 1.410.3 ± 1.5 b 
MB511.8 ± 1.3 a,b10.6 ± 1.1 a11.7 ± 1.311.2 ± 1.510.1 ± 1.710.0 ± 1.410.9 ± 1.4 b 
MB2012.2 ± 1.2 a,b10.5 ± 1.8 a10.8 ± 2.010.1 ± 1.79.9 ± 1.89.7 ± 1.910.3 ± 1.4 b 
  1. Legend: Data are expressed as mean ± SD. The reperfusion column represents the average value of the different periods of reperfusion
  2. a Significant difference (P < 0.05) between baseline and ischemia. b Significant difference (P < 0.05) between baseline and reperfusion. c Significant difference (P < 0.05) between reperfusion and ischemia
  3. ♯. Significant difference (P < 0.05) between Control and MB5 in reperfusion. Significant difference (P < 0.05) between Control and MB20 in reperfusion.
  4. †. Significant difference (p < 0.05) between MB5 and MB20 in reperfusion