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Table 1 Haemodynamic parameters in control (C) and methylene blue groups (MB5 and MB20)

From: Assessment of effects of methylene blue on intestinal ischemia and reperfusion in a rabbit model: hemodynamic, histological and immunohistochemical study

Variables

Group

Basaline

Ischemia

R60

R120

R240

R360

Reperfusion

HR (bpm)

C

207 ± 32 a

175 ± 41a

173 ± 31

178 ± 27

184 ± 28

190 ± 28

179 ± 29

♯,●

MB5

200 ± 18 a

182 ± 16 a,c

197 ± 28

209 ± 25

213 ± 24

216 ± 20

207 ± 26 c

♯,†

MB20

199 ± 23 a

176 ± 23 a,c

183 ± 26

198 ± 29

194 ± 37

200 ± 34

190 ± 30 c

●,†

RR (rpm)

C

35 ± 9

32 ± 8

36 ± 12

328

3510

3510

34 ± 10

♯,●

MB5

37 ± 10

35 ± 5 c

41 ± 8

436

4810

4610

43 ± 9 c

♯

MB20

34 ± 7

33 ± 8 c

35 ± 8

4013

4212

4514

40 ± 12 c

●

MAP (mmHg)

C

64 ± 6 a,b

41 ± 13 a

41 ± 11

42 ± 11

41 ± 10

38 ± 11

40 ± 10 b

♯,●

MB5

66 ± 15 a

46 ± 13 a,c

65 ± 15

58 ± 13

56 ± 13

55 ± 12

59 ± 14 c

♯,†

MB20

61 ± 14 ª,b

47 ± 10 a

50 ± 9

45 ± 9

45 ± 7

46 ± 8

47 ± 9b

●,†

SAP (mmHg)

C

84 ± 12 a,b

52 ± 15 a

56 ± 14

59 ± 12

56 ± 12

52 ± 13

56 ± 13 b

♯,●

MB5

89 ± 23 a

60 ± 18 a,c

95 ± 21

84 ± 15

79 ± 14

75 ± 14

85 ± 18 c

♯,†

MB20

83 ± 19 a

62 ± 17 a

78 ± 17

70 ± 18

66 ± 14

69 ± 14

72 ± 17

●,†

DAP (mmHg)

C

51 ± 6 a,b

35 ± 11 a

32 ± 9

33 ± 10

33 ± 8

30 ± 9

31 ± 9 b

♯,●

MB5

52 ± 14 a

39 ± 11 a,c

49 ± 12

45 ± 11

42 ± 10

42 ± 10

45 ± 11 c

♯,†

MB20

45 ± 13 a,b

37 ± 10 a

35 ± 9

33 ± 7

35 ± 6

37 ± 9

36 ± 6 b

†,●

CI (mL/min/kg)

C

177 ± 52 a,b

115 ± 53 a

124 ± 49

126 ± 28

110 ± 16

127 ± 27

123 ± 39 b

♯,●

MB5

190 ± 33 a

103 ± 29 a,c

172 ± 47

191 ± 53

186 ± 51

183 ± 45

182 ± 50 c

♯

MB20

189 ± 39 a

111 ± 32 a,c

185 ± 68

168 ± 56

165 ± 60

177 ± 73

175 ± 63 c

●

dPmx (mmHg/s)

C

888 ± 363 a,b

488 ± 161 a

628 ± 266

605 ± 274

535 ± 158

450 ± 128

584 ± 250 b

♯,●

MB5

941 ± 193 a

558 ± 237 a,c

1244 ± 357

1072 ± 253

930 ± 256

918 ± 194

1080 ± 314 c

♯

MB20

931 ± 276 a

577 ± 140 a,c

1218 ± 403

916 ± 463

874 ± 390

1017 ± 405

1031 ± 442 c

●

SVI (mL/beat/kg)

C

0.88 ± 0.31 a

0.68 ± 0.30 a

0.73 ± 0.32

0.71 ± 0.18

0.55 ± 0.17

0.62 ± 0.16

0.69 ± 0.26

♯,●

MB5

0.95 ± 0.15 a

0.54 ± 0.13 a,c

0.93 ± 0.34

0.98 ± 0.34

0.92 ± 0.30

0.89 ± 0.32

0.94 ± 0.32 c

♯

MB20

0.98 ± 0.26 a

0.65 ± 0.20 a,c

1.00 ± 0.36

0.83 ± 0.20

0.82 ± 0.22

0.89 ± 0.25

0.91 ± 0.30 c

●

SVRI (mmHg/mL/min/kg)

C

0.37 ± 0.10 a

0.40 ± 0.18 a,c

0.33 ± 0.13

0.30 ± 0.08

0.32 ± 0.07

0.25 ± 0.1

0.30 ± 0.10 c

♯

MB5

0.33 ± 0.09 a

0.44 ± 0.15 a,c

0.34 ± 0.07

0.32 ± 0.06

0.30 ± 0.08

0.31 ± 0.09

0.33 ± 0.11 c

♯,†

MB20

0.31 ± 0.11 a

0.42 ± 0.13 a,c

0.26 ± 0.10

0.27 ± 0.06

0.32 ± 0.07

0.30 ± 0.19

0.28 ± 0.09 c

†

CaO2 (mL/dL)

C

16.4 ± 1.2 a,b

14.2 ± 1.7 a

15.1 ± 1.6

14.8 ± 1.4

13.8 ± 0.9

12.1 ± 1.9

14.8 ± 2.1 b

 

MB5

15.7 ± 1.8 a,b

14.7 ± 1.5 a

15.6 ± 1.5

14.8 ± 1.5

13.9 ± 1.7

13.5 ± 1.9

14.4 ± 2.1 b

†

MB20

16.1 ± 1.1 a,b

14.1 ± 2.5 a

13.8 ± 2.6

13.1 ± 2.2

12.7 ± 2.5

12.3 ± 2.7

13.3 ± 2.6 b

†

DO2 (mL/min/kg)

C

29.3 ± 8.3 a,b

15.9 ± 8.8 a

19.2 ± 5.9

16.2 ± 4.2

14.7 ± 4.1

14.8 ± 3.0

16.4 ± 4.6 b

♯,●

MB5

29.5 ± 7.9 a

15.7 ± 7.1 a,c

25.7 ± 6.4

27.0 ± 4.9

24.8 ± 6.7

20.0 ± 7.4

24.4 ± 6.3 c

♯

MB20

30.1 ± 8.6 a

15.6 ± 4.5 a,c

28.5 ± 13.9

24.5 ± 5.6

21.9 ± 8.2

19.7 ± 8.5

23.6 ± 10.5 c

●

VVS (%)

C

12 ± 2 a,b

22 ± 7 a

19 ± 5

21 ± 6

21 ± 5

24 ± 7

20 ± 5 b

♯

MB5

10 ± 3 a

19 ± 6 a,c

15 ± 4

15 ± 6

13 ± 5

12 ± 3

14 ± 5 c

♯,†

MB20

12 ± 3 a,b

19 ± 5 a

17 ± 6

17 ± 8

19 ± 9

19 ± 10

18 ± 8 b

†

Lactate (mmol/L)

C

2.8 ± 1.1 a,b

5.6 ± 1.8 a

7.7 ± 2.0

6.6 ± 2.4

6.0 ± 1.7

5.7 ± 1.9

6.9 ± 2.6 b

♯

MB5

2.4 ± 1.0 a,b

4.9 ± 1.3 a,

5.5 ± 1.2

4.7 ± 1.7

4.3 ± 1.4

4.5 ± 1.4

4.8 ± 1.2 b

♯,†

MB20

2.8 ± 0.9 a,b

5.2 ± 1.9a

6.3 ± 2.1

6.4 ± 3.1

6.0 ± 3.0

5.5 ± 2.4

6.1 ± 2.4 b

†

Hemoglobine (gr/dL)

C

12.3 ± 1.1 a,b

10.4 ± 1.4 a

10.9 ± 1.6

10.7 ± 1.5

9.2 ± 1.6

8.9 ± 1.4

10.3 ± 1.5 b

 

MB5

11.8 ± 1.3 a,b

10.6 ± 1.1 a

11.7 ± 1.3

11.2 ± 1.5

10.1 ± 1.7

10.0 ± 1.4

10.9 ± 1.4 b

 

MB20

12.2 ± 1.2 a,b

10.5 ± 1.8 a

10.8 ± 2.0

10.1 ± 1.7

9.9 ± 1.8

9.7 ± 1.9

10.3 ± 1.4 b

 
  1. Legend: Data are expressed as mean ± SD. The reperfusion column represents the average value of the different periods of reperfusion
  2. a Significant difference (P < 0.05) between baseline and ischemia. b Significant difference (P < 0.05) between baseline and reperfusion. c Significant difference (P < 0.05) between reperfusion and ischemia
  3. ♯. Significant difference (P < 0.05) between Control and MB5 in reperfusion. ● Significant difference (P < 0.05) between Control and MB20 in reperfusion.
  4. †. Significant difference (p < 0.05) between MB5 and MB20 in reperfusion
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BMC Veterinary Research

ISSN: 1746-6148

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