Fig. 8

Secretion of VEGFA, measured with ELISA, by uterine endothelial cells cultured in vitro and stimulated for 24 h with media conditioned by uterine slices from non-adenomyotic uterine tissue (healthy) and from adenomyosis in stages 3–4 (adenomyotic). Additionally, uterine slices were treated with E2 or P4 and non-treated control (control). Bars represent the mean ± SEM. *** P < 0.001 indicates statistically significant difference in effects of E2 treatment between non-adenomyotic and adenomyotic group. Pound signs indicate statistically significant differences between treatments comparing to non-treated control within groups of non-adenomyotic or adenomyotic uterine tissues. ### P < 0.001. P < 0.05 was considered as significant, and was determined using two-way ANOVA, followed by Bonferroni’s post-hoc test