Fig. 5
From: Characterization of five newly derived canine osteosarcoma cell lines
Degree of Osteogenic Differentiation in Osteosarcoma Cell Lines. Exposure to osteogenic differentiation media (ODM) demonstrated that 3 of 4 cell lines tested were able to produce a significantly higher number of bone islands than controls. The TOT cell line was surprisingly resistant to the ODM with a significant decrease in the ability to produce bone islands after exposure to ODM. Abrams exceeded the other cell lines in its ability to produce osteoid islands.