Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs

Table 1 Concentrations of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) in Canine and Human Market Formulations Administered to Dogs

Product	[Mean KBA] Detected (mg/g)^§	[Mean AKBA] Detected (mg/g)^§	[AKBA] Label Claim (mg/g)^§	Detected AKBA as % of Label Claim
CMF 1^‡	2.0	2.5
CMF 2^‡	24.8	8.8
CMF 3^‡	8.9	0.1
CMF 4^‡	0.3	0.4
CMF 5^‡	0.02	1.7
CMF 6^‡	0	2.7
CMF 7^†‡	0.6	56.2	49.4	114
HMF 1^†‡	0.1	12.7	7.1	180
HMF 2^†‡	0	118.4	64.6	183
HMF 3^†‡	0	147.9	66	224
HMF 4^‡	15.7	23.5
HMF 5^‡	14.8	19.2
HMF 6^†‡	0	155.7	94	166

† Formulations with a label claim for concentration of AKBA
‡ Product names and manufacturers for the market formulations tested: CMF 1: Advanced Hip & Joint, Springtime Inc., Cockeysville, MD; CMF 2: Boswellia Herbal Joint Support, Platinum Performance, Buellton, CA; CMF 3: S.O.D. & Boswellia Extra Joint Support, NaturVet, Temecula, CA; CMF 4: Synovi G4 Soft Chews for Dogs, Bayer, Shawnee Mission, KS; CMF 5: Cosequin Std Strength Plus Boswellia & HA Chewable Tablets, Nutramax Laboratories Veterinary Sciences, Inc., Lancaster, SC; CMF 6: Dasuquin Advanced Small to Medium Dogs Chewable Tablets, Nutramax Laboratories Veterinary Sciences, Inc., Lancaster, SC; CMF 7: Maximus Joint Booster (UC-II), PETdiatric Laboratories, Selangor, Malaysia; HMF 1: Flex-a-min Triple Strength with Joint Flex, Nature’s Bounty, Bohemia, NY; HMF 2: Synergy 5-Loxin Boswellia serrata Extract, Vitacost, Boca Raton, FL; HMF 3: 5-LOX Inhibitor with Apresflex, Life Extension, Fort Lauderdale, FL; HMF 4: Boswellia Extract 500 mg Capsules, NOW Foods, Bloomingdale, IL; HMF 5: Organic Frankincense Powder, Starwest Botanicals, Sacramento, CA; HMF 6: Boswellia AKBA 5-Loxin, Pure Encapsulations, LLC., Sudbury, MA
§ Units of mg/g refer to products as fed

ISSN: 1746-6148