PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs

BMC Veterinary Research

Table 2 Results for fitting of the Hill equation

Parameter	Healthy pigs	Infected pigs
E_max (lg CFU)	−6.449	− 6.543
EC₅₀ (h)	124.247	241.774
E₀ (lg CFU)	2.268	2.120
N	10.000	2.171
(C_{e E = 0}) AUC_{24 h}/MIC for bacteriostatic action (h)	28.406	36.006
(C_{e E = -3}) AUC_{24 h}/MIC for bactericidal action (h)	29.516	71.637
(C_{e E = -4}) AUC_{24 h}/MIC for bacteriophagous action (h)	29.913	90.619
Dose (C_{e E = 0}) (mg/kg)	0.473	0.599
Dose (C_{e E = -3}) (mg/kg)	0.492	1.191
Dose (C_{e E = -4}) (mg/kg)	0.499	1.507

AUC represents the area under the curve; MIC is the minimum inhibitory concentration; E₀ represents the maximum difference in the logarithm of the bacterial count after 24 h of bacterial culture in the blank group; E_max is the maximum difference in the logarithm of the bacterial count after 24 h of bacterial culture in the serum sample; EC₅₀ represents the AUC/MIC when reaching 50% of the maximum antibacterial effect in the serum sample; N is the slope of the equation (no unit)

ISSN: 1746-6148