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Table 1 Demographic data, laboratory analyses, gastrointestinal endoscopic scores and glomerular filtration rate

From: Safety and efficacy of reduced dosage ketoprofen with or without tramadol for long-term treatment of osteoarthritis in dogs: a randomized clinical trial

 

Reference range

Group A

Group B

Group C

Sex

 Male (n)

 

2

7

6

 Female (n)

 

3

3

4

Age (years)

 

4.4(0.5)

10.3(1.8)

9.1(3.7)

Body weight (kg)

 

12.2(1.9)a

36.4(7.4)

38.6(11.8)

Osteoarthritis radiographic score (no unit)

0–9

Not applicable

6.7(3.3)

5.8(2.9)

Affected joints

• Bilateral hips

 

n = 3

n = 3

• Stifle (right)

 

n = 2

n = 3

• Bilateral hips and shoulders

 

n = 1

n = 3

• Bilateral hips and elbow

 

n = 2

n = 1

• Bilateral elbows

 

n = 1

 

• Shoulder (right)

 

n = 1

 

Duration of clinical signs evolution (months)

As reported by the owners

 

4.1(1.8)

5.6(2.4)

Red blood cell count (M/mm3)

5.5–8.5

6.8(0.7)

7.2(1.1)

7.5(0.6)

Hematocrit (%)

37–54

50.9(4.6)

44.6(7.8)

49.4(6.4)

Hemoglobin concentration (g/dL)

12–18

15.9(1.3)

16.4(2.9)

15.8(1.9)

Mean corpuscular volume (μ3)

60–77

75.2(0.8)

67.6(1.0)

71.2(3.4)

Mean corpuscular hemoglobin concentration (g/dL)

31–36

31.3(0.2)

34.3(1.8)

32.6(3.1)

Leucocyte count (m/mm3)

6–17

5.5(0.6)

7.2(3.2)

9.8(2.6)

Platelet count (m/mm3)

160–525

450.8(95.2)

448(122.2)

384.8(118.4)

Blood urea nitrogen (mEq/L)

2.1–9.7

4.2(1.1)

5.8(1.4)

4.8(0.9)

Creatinine (μmol/L)

42–135

62(10.8)

93.3(14.4)

82.5(13.2)

Alkaline phosphatase (UI/L)

0–200

61.0(15.1)

53.6(28.8)

92.4(86.2)

Alanine aminotransferase (UI/L)

0–130

52.2(38.4)

46.2(28.8)

38.2(16.7)

Platelet aggregation time (seconds)

0–213

133.6(17.7)

178.2(32.4)

168.7(38.5)

Gastrointestinal endoscopic score (no unit)

0–50

2.4(1.8)

1.6(1.5)

1.1(1.6)

Glomerular filtration rate (mL/min/m2)

55–117.1

97.2(7.15)

87.9(14.1)

94.6(12.9)

  1. Data from baseline evaluation (D0). Group A refers to healthy dogs and Groups B and C refer to dogs with osteoarthritis. Data are presented as mean(SD)
  2. aDifference statistically significant among groups