Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs

Table 4 Modified Canine Atopic Dermatitis Extent and Severity Index scores recorded by veterinarians during the study period

Dermatological site	Visit			P-value
Dermatological site	Initial	4 weeks	8 weeks	P-value
Dog total	19 (3–69)^a	11 (1–51)^b	7 (3–46)^bc	0.0001
Chin, Lips & Face (left and right combined)	3 (0–8)^a	1 (0–6)^b	0 (0–5)^bc	0.0003
Medial Pinnae (concave pinnae)	2 (0–11)	2 (0–9)	1 (0–5)	0.1046
Axillae	2 (0–10)^a	0 (0–6)^ab	0 (0–4)^b	0.0020
Front Paws (dorsal and palmar sides combined)	3 (0–7)^a	1 (0–4)^b	1 (0–4)^ab	0.0017
Hind Paws (dorsal and plantar sides combined)	3 (0–7)	1 (0–7)	1 (0–10)	0.2224
Cubital Flexor (elbow folds)	0 (0–13)	0 (0–4)	0 (0–4)	0.0490
Palmar Metacarpal (from carpal to metacarpal pads)	0 (0–4)	0 (0–4)	0 (0–4)	0.1673
Dorsum, Flanks & Tail Base	0 (0–11)^a	0 (0–6)^a	0 (0–2)^a	0.0383
Inguinal Areas†	1 (0–10)^a	1 (0–6)^b	0 (0–4)^ab	0.0337
Abdomen	1 (0–10)	1 (0–8)	0 (0–4)	0.1619
Perineum	0 (0–9)	0 (0–6)	0 (0–4)	0.1058
Ventral Tail (proximal)	0 (0–8)	0 (0–4)	0 (0–4)	0.1353

Legend: Modified Canine Atopic Dermatitis Extent and Severity Index scores recorded by veterinarians during the study period. Data are reported as median (range). Data were available for 17 dogs during the initial examination and at 4 weeks, and for 13 dogs at 8 weeks
^a,b,c Within each row, time points with different letters are significantly different (Friedman’s chi-square with Bonferroni adjustment < 0.05)
^† Statistical significance is not robust for this region (Statistical test looks at the entire distribution. For borderline cases, it is possible to have statistical significance with equal medians)

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