Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion

BMC Veterinary Research

Table 3 Average optical density values of BCRP and MRP4 in the liver, kidney, jejunum, and ileum in all treatment groups based on immunohistochemistry

Protein	Item	NC	SD	FM	IU
BCRP	Liver	0.039 ± 0.0032	0.027 ± 0.0058	0.045 ± 0.0046	0.027 ± 0.003
	kidney	0.081 ± 0.0031	0.125 ± 0.0081^**	0.198 ± 0.0128^**	0.211 ± 0.0061^**
	Jejunum	0.067 ± 0.0034	0.064 ± 0.0022	0.054 ± 0.0036	0.050 ± 0.0158
	Ileum	0.062 ± 0.0078	0.131 ± 0.0021^**	0.083 ± 0.0028^*	0.197 ± 0.0067^**
MRP4	Liver	0.035 ± 0.0017	0.022 ± 0.0016^**	0.040 ± 0.0039	0.029 ± 0.0023
	kidney	0.097 ± 0.0043	0.115 ± 0.0092	0.165 ± 0.0007^**	0.202 ± 0.0074^**
	Jejunum	0.064 ± 0.0025	0.052 ± 0.0020	0.048 ± 0.0074	0.045 ± 0.0079
	Ileum	0.060 ± 0.0046	0.081 ± 0.0113	0.068 ± 0.0056	0.125 ± 0.0047^**

^*P < 0.05, ^**P < 0.01 compared with the NC group
NC: control group; SD: sulfonamide-supplemented group; FM: fish meal group; IU: injection uric acid group. All data are means ± SE; N = 9 samples per treatment

ISSN: 1746-6148