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Table 2 Relationship between SPHK1 expression and histopathological factors

From: Significance of sphingosine kinase 1 expression in feline mammary tumors

  SPHK1 positive Lower 95% CI Upper 95% CI p-value
Histologic grade (Elston and Ellis)
 Grade 1 50.88% 37.29% 64.37% 0.024
 Grade 2 79.17% 57.85% 92.87%  
 Grade 3 71.43% 29.04% 96.33%  
Histologic grade (Mills et al.) 0.0009
 Grade 1 41.86% 27.01% 57.87%  
 Grade 2 73.33% 54.11% 87.72%  
 Grade 3 86.67% 59.54% 98.34%  
Tubule formation 0.112
  < 10% 47.83% 26.82% 69.41%  
 10–75% 69.23% 52.43% 82.98%
  > 75% 57.69% 36.92% 76.65%  
Nuclear pleomorphism 0.099
  < 5% abnormal 48.98% 34.42% 63.66%  
  > 5% abnormal 74.36% 57.87% 86.96%  
Mitotic count 0.457
  < 62 58.75% 47.18% 69.65%  
  > 62 75.00% 34.91% 96.81%  
Lymphovascular invasion 0.016
 Absent 49.23% 36.60% 61.93%  
 Present 91.30% 71.96% 98.93%  
Lymphocytic infiltration 0.112
 Absent 70.59% 56.17% 82.51%  
 Present 45.95% 29.41% 63.01%  
Ulceration 0.433
 Absent 42.86% 57.14% 9.9%  
 Present 61.73% 38.27% 50.26%  
Necrosis 0.429
 Absent 52% 48% 31.31%  
 Present 63.49% 36.51% 50.4%