Table 2 Relationship between SPHK1 expression and histopathological factors
From: Significance of sphingosine kinase 1 expression in feline mammary tumors
| Â | SPHK1 positive | Lower 95% CI | Upper 95% CI | p-value |
|---|---|---|---|---|
Histologic grade (Elston and Ellis) | ||||
 Grade 1 | 50.88% | 37.29% | 64.37% | 0.024 |
 Grade 2 | 79.17% | 57.85% | 92.87% |  |
 Grade 3 | 71.43% | 29.04% | 96.33% |  |
Histologic grade (Mills et al.) | 0.0009 | |||
 Grade 1 | 41.86% | 27.01% | 57.87% |  |
 Grade 2 | 73.33% | 54.11% | 87.72% |  |
 Grade 3 | 86.67% | 59.54% | 98.34% |  |
Tubule formation | 0.112 | |||
  < 10% | 47.83% | 26.82% | 69.41% |  |
 10–75% | 69.23% | 52.43% | 82.98% | |
  > 75% | 57.69% | 36.92% | 76.65% |  |
Nuclear pleomorphism | 0.099 | |||
  < 5% abnormal | 48.98% | 34.42% | 63.66% |  |
  > 5% abnormal | 74.36% | 57.87% | 86.96% |  |
Mitotic count | 0.457 | |||
  < 62 | 58.75% | 47.18% | 69.65% |  |
  > 62 | 75.00% | 34.91% | 96.81% |  |
Lymphovascular invasion | 0.016 | |||
 Absent | 49.23% | 36.60% | 61.93% |  |
 Present | 91.30% | 71.96% | 98.93% |  |
Lymphocytic infiltration | 0.112 | |||
 Absent | 70.59% | 56.17% | 82.51% |  |
 Present | 45.95% | 29.41% | 63.01% |  |
Ulceration | 0.433 | |||
 Absent | 42.86% | 57.14% | 9.9% |  |
 Present | 61.73% | 38.27% | 50.26% |  |
Necrosis | 0.429 | |||
 Absent | 52% | 48% | 31.31% |  |
 Present | 63.49% | 36.51% | 50.4% |  |