Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

Tresch, Milena; Mevissen, Meike; Ayrle, Hannah; Melzig, Matthias; Roosje, Petra; Walkenhorst, Michael

doi:10.1186/s12917-019-1854-4

BMC Veterinary Research

Table 3 Summary of the amount of references proving (+), giving an unclear result (?), showing no effect (0) or showing the opposite effect (−) for each criterion investigated for each plant species

From: Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

Type of reference		Calendula		Hypericum		Matricaria		Salvia
Type of reference		in vitro	in vivo + clinical	in vitro	in vivo + clinical	in vitro	in vivo + clinical	in vitro	in vivo + clinical
Anti-bacterial	+	7¹		19²		11³	1⁴	20⁵
	?			1⁶	1⁷
	0			1⁸		3⁹		1¹⁰
	–
Synergism with antibiotics/ disinfectants	+					1¹¹		4¹²
	?
	0							1¹³
	–
Anti-fungal	+	3¹⁴		10¹⁵		5¹⁶		7¹⁷
	?
	0	1¹⁸		4¹⁹		3²⁰		3²¹
	–
Anti-biofilm	+			3²²				2²³
	?
	0
	–
Anti-pruritic	+				1²⁴		3²⁵
	?						1²⁶
	0
	–
Wound-healing	+		8²⁷		8²⁸		5²⁹
	?				1³⁰
	0				1³¹
	–
Fibro-proliferative	+	3³²	1³³		1³⁴
	?			2³⁵
	0	1³⁶			3³⁷	2³⁸	1³⁹
	–			2⁴⁰	1⁴¹
Fibro-migrative	+	2⁴²		2⁴³
	?
	0					1⁴⁴
	–			1⁴⁵
Collagen-enhancing	+	1⁴⁶	2⁴⁷	2⁴⁸	4⁴⁹		1⁵⁰
	?
	0				1⁵¹
	–
Pro-angiogenic	+	2⁵²	3⁵³		3⁵⁴
	?
	0				3⁵⁵
	–			1⁵⁶
Anti-inflammatory	+		1⁵⁷	2⁵⁸	3⁵⁹		3⁶⁰	1⁶¹	2⁶²
	?		1⁶³		1⁶⁴
	0				2⁶⁵		1⁶⁶
	–	1⁶⁷
Anti-erythematous	+		1⁶⁸		2⁶⁹		2⁷⁰		2⁷¹
	?						1⁷²
	0				2⁷³
	–
Anti-edematous	+				3⁷⁴		1⁷⁵		1⁷⁶
	?
	0				1⁷⁷
	–
Analgesic	+				2⁷⁸		2⁷⁹
	?
	0
	–
Beneficial for skin	+		2⁸⁰		3⁸¹		1⁸²
	?
	0				1⁸³
	–
Hypothesis proven	+	2⁸⁴	4⁸⁵	5⁸⁶	10⁸⁷	2⁸⁸	5⁸⁹	3⁹⁰	1⁹¹
	?						1⁹²
	0					1⁹³	1⁹⁴
	–	1⁹⁵
Total	+	20	22	43	40	19	24	37	6
	?	0	1	3	3	0	3	0	0
	0	2	0	5	14	10	3	3	0
	–	2	0	4	1	0	0	0	0

¹[62, 65,66,67,68,69,70]; ² [53, 76,77,78, 138,139,140,141,142,143,144,145,146,147,148,149,150,151,152]; ³ [66, 68, 93, 97, 98, 100, 153,154,155,156,157]; ⁴ [158]; ⁵ [38, 93, 118, 119, 123,124,125,126, 157, 159,160,161,162,163,164,165,166,167,168,169]; ⁶ [170]; ⁷ [171];⁸ [172]; ⁹ [102, 103, 173]; ¹⁰ [174];; ¹¹ [93]; ¹² [93, 117,118,119]; ¹³ [167] ¹⁴ [65, 69, 175]; ¹⁵ [76, 79, 139,140,141, 151, 177, 178, 176, 179]; ¹⁶ [97]; ¹⁷ [120,121,122]; ¹⁸ [68]; ¹⁹ [78, 138, 152, 170]; ²⁰ [68, 102, 103]; ²¹ [160, 166, 180]; ²² [79, 149, 150]; ²³ [168, 181]; ²⁴ [82]; ²⁵ [35, 37, 104]; ²⁶ [182]; ²⁷ [29, 57,58,59,60,61,62,63]; ²⁸ [31, 32, 82, 84, 87, 88, 183, 184]; ²⁹ [104]; ³⁰ [81];³¹ [185]; ³² [29, 64, 186]; ³³ [29]; ³⁴ [183]; ³⁵ [45, 143];³⁶ [187]; ³⁷ [84, 86, 185]; ³⁸ [64, 187]; ³⁹ [105]; ⁴⁰ [52, 64]; ⁴¹ [87]; ⁴² [29, 64]; ⁴³ [45, 188]; ⁴⁴ [64]; ⁴⁵ [52]; ⁴⁶ [189]; ⁴⁷ [61, 62]; ⁴⁸ [45, 188]; ⁴⁹ [32, 86, 88, 183]; ⁵⁰ [105]; ⁵¹ [185]; ⁵² [62, 190]; ⁵³ [29, 62, 190]; ⁵⁴ [86, 88, 183]; ⁵⁵ [84, 87, 185]; ⁵⁶ [191]; ⁵⁷ [62]; ⁵⁸ [33, 83]; ⁵⁹ [33, 84, 85]; ⁶⁰ [35, 104, 109]; ⁶¹ [192]; ⁶² [55, 193]; ⁶³ [61]; ⁶⁴ [88];⁶⁵ [86, 87]; ⁶⁶ [105]; ⁶⁷ [189]; ⁶⁸ [71] ⁶⁹ [81, 194]; ⁷⁰ [37, 109]; ⁷¹ [55, 193]; ⁷² [182];⁷³ [88, 92]; ⁷⁴ [32, 81, 82]; ⁷⁵ [109]; ⁷⁶ [55]; ⁷⁷ [88]; ⁷⁸ [81, 82]; ⁷⁹ [104, 113]; ⁸⁰ [71, 72] ⁸¹ [84, 86, 87]; ⁸² [115]; ⁸³ [92] ⁸⁴ [29, 50]; ⁸⁵ [29, 30, 60, 195]; ⁸⁶ [33, 52, 83, 143, 191]; ⁸⁷ [31, 81, 82, 88, 92, 171, 185, 194]; ⁸⁸ [34, 36]; ⁸⁹ [35, 37, 108, 109, 115]; ⁹⁰ [39, 120, 192]; ⁹¹ [38]; ⁹² [182];⁹³ [196]; ⁹⁴ [197]; ⁹⁵ [189]

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ISSN: 1746-6148

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