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Table 2 Distribution of PrPCWD deposits in peripheral nerves, glands and organs of clinically affected and non-inoculated white-tailed deer

From: Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer

  Non-inoculated
wt/wt
Genotype wt/wt S96/wt H95/wt H95/S96
D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12
Optic nerve ++ + ++ + + + / + + ++ / –
Vagus nerve ++ + + / / + – + – + – –
Brachial plexus / – – / / – – / / – – –
Sciatic nerve + + – / – – / – – – – –
Pituitary gland / ++ +++ / / +++ +++ +++ / +++ – –
Islets of Langerhans ++ ++ ++ ++ ++ ++ + + – – / –
Adrenal Gl medulla +++ +++ +++ +++ ++ +++ +++ +++ + ++ / –
Ileoc. Valve villi/crypts ++ + + + ++ ++ ++ / – – – –
Kidney ++a + + + + / + + – – – –
Parotid salivary gland + + – / + + – + – / / –
Submandibular sal. Gl / + – / + + + + – – / –
Sublingual sal. Gl / – – / / – – – – – / –
Retina +++ +++ +++ + +++ +++ + +++ ++ ++ / –
Skeletal muscle – – – – – – – – – – – –
Heart / / / / / ++ / / – – / /
Lung + a – – – – – – – – – – –
Liver – – – – – – – – – – – –
  1. PrPCWD deposition was detected by IHC
  2. aDeer showing inflammatory kidney disease and lung interstitial inflammation / Sample not available for evaluation
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