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Table 2 Distribution of PrPCWD deposits in peripheral nerves, glands and organs of clinically affected and non-inoculated white-tailed deer

From: Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer

  Non-inoculated
wt/wt
Genotype wt/wt S96/wt H95/wt H95/S96
D1 D2 D3 D4 D5 D6 D7 D8 D9 D10 D11 D12
Optic nerve ++ + ++ + + + / + + ++ /
Vagus nerve ++ + + / / + + +
Brachial plexus / / / / /
Sciatic nerve + + / /
Pituitary gland / ++ +++ / / +++ +++ +++ / +++
Islets of Langerhans ++ ++ ++ ++ ++ ++ + + /
Adrenal Gl medulla +++ +++ +++ +++ ++ +++ +++ +++ + ++ /
Ileoc. Valve villi/crypts ++ + + + ++ ++ ++ /
Kidney ++a + + + + / + +
Parotid salivary gland + + / + + + / /
Submandibular sal. Gl / + / + + + + /
Sublingual sal. Gl / / / /
Retina +++ +++ +++ + +++ +++ + +++ ++ ++ /
Skeletal muscle
Heart / / / / / ++ / / / /
Lung + a
Liver
  1. PrPCWD deposition was detected by IHC
  2. aDeer showing inflammatory kidney disease and lung interstitial inflammation / Sample not available for evaluation