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Table 4 Comprehensive literature review: Treatment at the time of disease control

From: Feline pemphigus foliaceus: original case series and a comprehensive literature review

Treatment Regimen Number of Cats (%) Treated Time to Disease Control (days) Drug Dosages at the Time of Disease Control (median, mean and range (mg/kg/day))
Median Mean Range nonsteroidal drug oral glucocorticoid
Median Mean Range Median Mean Range
Oral Glucocorticoid Monotherapy (all) 76 (62%) 14 21 (7–70)       
prednisolone 49 (40%) 14 21 (7–70)     2 2 (0.5–6)
triamcinolone 15 (12%) nr nr nr     nr nr (0.6–2)
prednisone 10 (8%) nr nr nr     4 4 (1.5–5)
dexamethasone 2 (2%) nr nr nr     nr nr nr
Non-Steroidal Immunosuppressants as a Monotherapy or Combination Therapy 47 (38%)          
Chlorambucil + Oral Glucocorticoid (all) 23 (19%) 32 36 (14–78)       
chlorambucil + prednisone 9 (7%) nr nr nr nr nr nr nr nr nr
chlorambucil + prednisolone 8 (7%) 32 36 (19–78) 0.1 0.2 (0.1–0.3) 3 4 (1.6–8)
chlorambucil + dexamethasone 4 (3%) 28 29 (14–45) 0.1 0.1 (0.1–0.2) 0.2 0.2 (0.1–0.4)
chlorambucil + triamcinolone 2 (2%) nr nr nr nr nr nr nr nr nr
Ciclosporin Monotherapy 2 (2%) 64 64 (55–73) 5 5 (5–5.6)    
Ciclosporin + Oral Glucocorticoid (all) 9 (7%) 37 41 (28–67) 5.1 5.3 (4.4–6.9)    
ciclosporin + dexamethasone 3 (3%) 35 34 (28–38) 5.3 5.1 (4.4–5.5) 0.2 0.2 (0.1–0.2)
ciclosporin + prednisolone 2 (2%) 42 42 (33–50) 5.1 5.1 (5–5.2) 2.6 2.6 (2–3.1)
ciclosporin + triamcinolone 2 (2%) 36 6 6 (5–6.9) 0.6 0.6 (0.4–0.9)
ciclosporin + prednisone 1 (1%) 67 4.8 3
ciclosporin + methylprednisolone 1 (1%) 42 nr nr
Azathioprine + prednisone 8 (7%) nr 21 (14–50) 1.1 mg/kg every other day 4.4 mg/kg/day
Gold Salts + Oral Glucocorticoids 5 (4%) nr aurothioglucose: 0.5 mg/kg/week    
  1. In some cats, disease control was induced with more than one treatment regimen; nr not reported