Table 4 Comprehensive literature review: Treatment at the time of disease control
From: Feline pemphigus foliaceus: original case series and a comprehensive literature review
Treatment Regimen | Number of Cats (%) Treated | Time to Disease Control (days) | Drug Dosages at the Time of Disease Control (median, mean and range (mg/kg/day)) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Median | Mean | Range | nonsteroidal drug | oral glucocorticoid | ||||||
Median | Mean | Range | Median | Mean | Range | |||||
Oral Glucocorticoid Monotherapy (all) | 76 (62%) | 14 | 21 | (7–70) |  |  |  |  |  |  |
 prednisolone | 49 (40%) | 14 | 21 | (7–70) |  |  |  | 2 | 2 | (0.5–6) |
 triamcinolone | 15 (12%) | nr | nr | nr |  |  |  | nr | nr | (0.6–2) |
 prednisone | 10 (8%) | nr | nr | nr |  |  |  | 4 | 4 | (1.5–5) |
 dexamethasone | 2 (2%) | nr | nr | nr |  |  |  | nr | nr | nr |
Non-Steroidal Immunosuppressants as a Monotherapy or Combination Therapy | 47 (38%) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Chlorambucil + Oral Glucocorticoid (all) | 23 (19%) | 32 | 36 | (14–78) |  |  |  |  |  |  |
 chlorambucil + prednisone | 9 (7%) | nr | nr | nr | nr | nr | nr | nr | nr | nr |
 chlorambucil + prednisolone | 8 (7%) | 32 | 36 | (19–78) | 0.1 | 0.2 | (0.1–0.3) | 3 | 4 | (1.6–8) |
 chlorambucil + dexamethasone | 4 (3%) | 28 | 29 | (14–45) | 0.1 | 0.1 | (0.1–0.2) | 0.2 | 0.2 | (0.1–0.4) |
 chlorambucil + triamcinolone | 2 (2%) | nr | nr | nr | nr | nr | nr | nr | nr | nr |
Ciclosporin Monotherapy | 2 (2%) | 64 | 64 | (55–73) | 5 | 5 | (5–5.6) |  |  |  |
Ciclosporin + Oral Glucocorticoid (all) | 9 (7%) | 37 | 41 | (28–67) | 5.1 | 5.3 | (4.4–6.9) |  |  |  |
 ciclosporin + dexamethasone | 3 (3%) | 35 | 34 | (28–38) | 5.3 | 5.1 | (4.4–5.5) | 0.2 | 0.2 | (0.1–0.2) |
 ciclosporin + prednisolone | 2 (2%) | 42 | 42 | (33–50) | 5.1 | 5.1 | (5–5.2) | 2.6 | 2.6 | (2–3.1) |
 ciclosporin + triamcinolone | 2 (2%) | 36 | 6 | 6 | (5–6.9) | 0.6 | 0.6 | (0.4–0.9) | ||
 ciclosporin + prednisone | 1 (1%) | 67 | 4.8 | 3 | ||||||
 ciclosporin + methylprednisolone | 1 (1%) | 42 | nr | nr | ||||||
Azathioprine + prednisone | 8 (7%) | nr | 21 | (14–50) | 1.1 mg/kg every other day | 4.4 mg/kg/day | ||||
Gold Salts + Oral Glucocorticoids | 5 (4%) | nr | aurothioglucose: 0.5 mg/kg/week |  |  |  | ||||