Table 4 Comprehensive literature review: Treatment at the time of disease control
From: Feline pemphigus foliaceus: original case series and a comprehensive literature review
| Treatment Regimen | Number of Cats (%) Treated | Time to Disease Control (days) | Drug Dosages at the Time of Disease Control (median, mean and range (mg/kg/day)) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median | Mean | Range | nonsteroidal drug | oral glucocorticoid | ||||||
| Median | Mean | Range | Median | Mean | Range | |||||
| Oral Glucocorticoid Monotherapy (all) | 76 (62%) | 14 | 21 | (7–70) | ||||||
| prednisolone | 49 (40%) | 14 | 21 | (7–70) | 2 | 2 | (0.5–6) | |||
| triamcinolone | 15 (12%) | nr | nr | nr | nr | nr | (0.6–2) | |||
| prednisone | 10 (8%) | nr | nr | nr | 4 | 4 | (1.5–5) | |||
| dexamethasone | 2 (2%) | nr | nr | nr | nr | nr | nr | |||
| Non-Steroidal Immunosuppressants as a Monotherapy or Combination Therapy | 47 (38%) | |||||||||
| Chlorambucil + Oral Glucocorticoid (all) | 23 (19%) | 32 | 36 | (14–78) | ||||||
| chlorambucil + prednisone | 9 (7%) | nr | nr | nr | nr | nr | nr | nr | nr | nr |
| chlorambucil + prednisolone | 8 (7%) | 32 | 36 | (19–78) | 0.1 | 0.2 | (0.1–0.3) | 3 | 4 | (1.6–8) |
| chlorambucil + dexamethasone | 4 (3%) | 28 | 29 | (14–45) | 0.1 | 0.1 | (0.1–0.2) | 0.2 | 0.2 | (0.1–0.4) |
| chlorambucil + triamcinolone | 2 (2%) | nr | nr | nr | nr | nr | nr | nr | nr | nr |
| Ciclosporin Monotherapy | 2 (2%) | 64 | 64 | (55–73) | 5 | 5 | (5–5.6) | |||
| Ciclosporin + Oral Glucocorticoid (all) | 9 (7%) | 37 | 41 | (28–67) | 5.1 | 5.3 | (4.4–6.9) | |||
| ciclosporin + dexamethasone | 3 (3%) | 35 | 34 | (28–38) | 5.3 | 5.1 | (4.4–5.5) | 0.2 | 0.2 | (0.1–0.2) |
| ciclosporin + prednisolone | 2 (2%) | 42 | 42 | (33–50) | 5.1 | 5.1 | (5–5.2) | 2.6 | 2.6 | (2–3.1) |
| ciclosporin + triamcinolone | 2 (2%) | 36 | 6 | 6 | (5–6.9) | 0.6 | 0.6 | (0.4–0.9) | ||
| ciclosporin + prednisone | 1 (1%) | 67 | 4.8 | 3 | ||||||
| ciclosporin + methylprednisolone | 1 (1%) | 42 | nr | nr | ||||||
| Azathioprine + prednisone | 8 (7%) | nr | 21 | (14–50) | 1.1 mg/kg every other day | 4.4 mg/kg/day | ||||
| Gold Salts + Oral Glucocorticoids | 5 (4%) | nr | aurothioglucose: 0.5 mg/kg/week | |||||||