Table 1 Changes in the complete blood count and oxidative damage markers in erythrocytes in dogs fed aged garlic extract (45 mg/kg or 90 mg/kg body weight once a day) for 12 weeks
Parameters | Dose (mg/kg) | Week 0 | Week 1 | Week 4 | Week 8 | Week 12 |
|---|---|---|---|---|---|---|
RBC | 0 (Control) | 7.68 ± 0.49 | 7.59 ± 0.68 | 7.48 ± 0.59 | 7.18 ± 0.62 | 7.40 ± 0.86 |
(106/μl) | 45 | 7.14 ± 0.71 | 7.40 ± 1.14 | 7.32 ± 0.78 | 6.97 ± 0.72 | 7.36 ± 0.59 |
|  | 90 | 7.38 ± 0.42 | 7.42 ± 0.64 | 6.93 ± 0.87 | 6.80 ± 0.80 | 7.34 ± 0.67 |
Hb | 0 (Control) | 17.0 ± 1.5 | 17.0 ± 2.3 | 16.5 ± 2.0 | 15.6 ± 1.9 | 16.4 ± 2.4 |
(g/dl) | 45 | 16.3 ± 1.9 | 16.9 ± 2.8 | 16.4 ± 1.9 | 15.5 ± 1.7 | 16.6 ± 1.6 |
|  | 90 | 16.3 ± 0.6 | 16.6 ± 0.7 | 15.4 ± 1.5 | 15.0 ± 1.2 | 16.3 ± 0.7 |
Ht | 0 (Control) | 50.6 ± 4.0 | 50.0 ± 5.9 | 49.0 ± 4.9 | 46.6 ± 5.1 | 47.8 ± 6.1 |
(%) | 45 | 47.4 ± 5.6 | 48.9 ± 7.8 | 48.1 ± 5.3 | 45.8 ± 5.0 | 47.7 ± 5.5 |
|  | 90 | 46.9 ± 2.2 | 47.2 ± 1.6 | 44.8 ± 3.3 | 43.7 ± 2.2 | 46.5 ± 1.8 |
MCV | 0 (Control) | 65.9 ± 4.3 | 65.9 ± 3.8 | 65.5 ± 3.8 | 64.9 ± 3.0 | 64.5 ± 2.7 |
(fl) | 45 | 66.3 ± 1.9 | 66.1 ± 1.8 | 65.8 ± 2.5 | 65.7 ± 2.3 | 64.6 ± 2.6 |
|  | 90 | 63.5 ± 2.7 | 63.9 ± 3.4 | 64.9 ± 3.5 | 64.6 ± 4.2 | 63.6 ± 3.9 |
MCH | 0 (Control) | 22.2 ± 1.1 | 22.3 ± 1.3 | 22.0 ± 1.2 | 21.8 ± 0.9 | 22.2 ± 0.8 |
(pg) | 45 | 22.8 ± 0.8 | 22.9 ± 0.9 | 22.4 ± 0.8 | 22.3 ± 0.8 | 22.5 ± 0.5 |
|  | 90 | 22.1 ± 0.8 | 22.5 ± 1.0 | 22.2 ± 0.8 | 22.1 ± 0.9 | 22.3 ± 1.1 |
MCHC | 0 (Control) | 33.7 ± 1.0 | 33.9 ± 1.1 | 33.6 ± 1.2 | 33.5 ± 1.1 | 34.4 ± 1.1 |
(g/dl) | 45 | 34.4 ± 0.5 | 34.6 ± 0.5 | 34.1 ± 0.1 | 33.9 ± 0.1 | 34.8 ± 0.7 |
|  | 90 | 34.7 ± 0.6 | 35.2 ± 0.5 | 34.4 ± 0.9 | 34.2 ± 1.1 | 35.2 ± 0.5 |
WBC | 0 (Control) | 10.9 ± 0.9 | 9.3 ± 0.5 | 9.8 ± 1.5 | 12.1 ± 1.7 | 11.2 ± 2.6 |
(103/μl) | 45 | 10.3 ± 0.8 | 9.8 ± 1.3 | 8.7 ± 1.2 | 10.4 ± 0.9 | 10.2 ± 0.7 |
|  | 90 | 12.3 ± 1.2 | 9.9 ± 1.1 | 10.6 ± 1.5 | 11.8 ± 3.2 | 10.3 ± 1.9 |
PLT | 0 (Control) | 341 ± 62 | 331 ± 51 | 349 ± 55 | 355 ± 33 | 379 ± 47 |
(103/μl) | 45 | 346 ± 48 | 339 ± 41 | 348 ± 101 | 342 ± 82 | 355 ± 157 |
|  | 90 | 325 ± 40 | 343 ± 125 | 357 ± 93 | 324 ± 45 | 336 ± 64 |
Reticulocyte | 0 (Control) | 8 ± 5 | 2 ± 1 | 7 ± 6 | 3 ± 1 | 3 ± 2 |
(‰) | 45 | 9 ± 5 | 8 ± 2* | 9 ± 6 | 7 ± 5 | 6 ± 3 |
|  | 90 | 5 ± 1 | 4 ± 1 | 5 ± 3 | 3 ± 1 | 4 ± 1 |
Heinz body | 0 (Control) | 0 | 0 | 0 | 0 | 0 |
(‰) | 45 | 0 | 0 | 0 | 0 | 0 |
| Â | 90 | 0 | 0 | 0 | 0 | 0 |
Eccentrocyte | 0 (Control) | 0 | 0 | 0 | 0 | 0 |
(‰) | 45 | 0 | 0 | 0 | 0 | 0 |
| Â | 90 | 0 | 0 | 0 | 0 | 0 |