Table 2 Pharmacokinetic parameters of enrofloxacin in serum after oral administration of 1, 10, and 20 mg/kg body weight enrofloxacin in E. coli O78-infected chicks (mean and SD, n = 10)
Parameters | 1 mg/kg | 10 mg/kg | 20 mg/kg |
|---|---|---|---|
Cmax (μg/mL) | 0.16 ± 0.041 | 1.76 ± 0.32 | 2.86 ± 0.52 |
Tmax (h) | 3.35 ± 1.8 | 3.4 ± 2.12 | 3.3 ± 1.77 |
T1/2β (h) | 10.75 ± 1.8 | 11.44 ± 1.41 | 9.78 ± 1.26 |
AUC0–24 (h·μg/mL) | 1.64 ± 0.28 | 17.95 ± 2.45 | 30.07 ± 4.64 |
CL/F (mL/h/kg) | 488 ± 114 | 420 ± 85 | 548 ± 114 |