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Table 1 Non-cutaneous clinical signs of AFR in dogs

From: Critically appraised topic on adverse food reactions of companion animals (6): prevalence of noncutaneous manifestations of adverse food reactions in dogs and cats

Clinical sign

Number of animals (% of all reported non-cutaneous AFR)

Strength of evidence

Diarrhoea [9,10,11,12,13,14,15,16,17,18,19, 22,23,24,25,26,27, 32,33,34,35,36,37,38,39,40,41,42,43,44, 47, 48]

391–490a (70–88%)

Strong in 36–39a [9,10,11,12,13,14,15,16,17,18,19, 48]

Moderate in 151–189a [22,23,24,25,26,27, 47]

Weak in 204–212a [32,33,34,35,36,37,38,39,40,41,42,43,44]

Vomiting [9, 11, 13,14,15, 17, 18, 22,23,24,25,26,27, 33, 34, 40, 42, 43]

28–115a (5–21%)

Strong in 6–47a [9, 11, 13,14,15, 17, 18]

Moderate in 5–43a [22,23,24,25,26,27]

Weak in 17–25 [33, 34, 40, 42, 43]

Increased frequency of defecation [23, 24, 45]

33 (6%)

Strong in 16 [45]

Moderate in 17 [23, 24]

Tenesmus [45]

11 (2%)

Strong in 11

Paroxysmal gluten-sensitive dyskinesia of Border terriers [49]

5 (1%)

Strong in 2

Weak in 3

Symmetrical lupoid onychodystrophy [50]

4 (1%)

Strong in 2

Weak in 2

Anaphylaxis [40]

1 (0.2%)

Weak

Conjunctivitis [12]

1 (0.2%)

Strong

Asthma [27]

1 (0.2%)

Moderate

Sneezing [14]

1 (0.2%)

Strong

  1. a Minimal and maximal number of dogs, as in some studies, the specific number of dogs showing some of the individual clinical signs was not reported