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Table 3 In vivo PK-PD parameter of tylosin afer IM administration at a dose rate of 10 mg/kg (n = 8)

From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

PK-PD parameter Unit Healthy Pigs Mean ± SD Infected Pigs Mean ± SD
AUC h·μg/mL 10.804 ± 2.204 10.297 ± 3.458
Cmax μg/mL 2.225 ± 0.485 2.442 ± 0.389
MIC μg/mL 0.250 0.250
MBC μg/mL 1.000 1.000
AUC24 h/MIC h 43.216 ± 8.816 41.188 ± 13.832
AUC24 h/MBC h 10.804 ± 2.204 10.297 ± 3.458
Cmax/MIC 8.900 ± 1.940 9.768 ± 1.556
Cmax/MBC 2.225 ± 0.485 2.442 ± 0.389
T>MIC h 8.863 ± 0.914 7.568 ± 2.220
T>MBC h 4.712 ± 0.756 4.327 ± 1.433