Table 3 In vivo PK-PD parameter of tylosin afer IM administration at a dose rate of 10 mg/kg (n = 8)
From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs
PK-PD parameter | Unit | Healthy Pigs Mean ± SD | Infected Pigs Mean ± SD |
|---|---|---|---|
AUC | h·μg/mL | 10.804 ± 2.204 | 10.297 ± 3.458 |
Cmax | μg/mL | 2.225 ± 0.485 | 2.442 ± 0.389 |
MIC | μg/mL | 0.250 | 0.250 |
MBC | μg/mL | 1.000 | 1.000 |
AUC24 h/MIC | h | 43.216 ± 8.816 | 41.188 ± 13.832 |
AUC24 h/MBC | h | 10.804 ± 2.204 | 10.297 ± 3.458 |
Cmax/MIC | – | 8.900 ± 1.940 | 9.768 ± 1.556 |
Cmax/MBC | – | 2.225 ± 0.485 | 2.442 ± 0.389 |
T>MIC | h | 8.863 ± 0.914 | 7.568 ± 2.220 |
T>MBC | h | 4.712 ± 0.756 | 4.327 ± 1.433 |