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Table 1 Haemodynamic variables in dogs (n = 8) receiving a bolus of 5 mg/kg of propofol, administered over 30 s IV, at different time points

From: Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring

  Pre-induction 30 s Tpeak
55 (50–60) sec
90 s 120 s 150 s 300 s
HR 65 (50–120) 76 (50–130) 105 (70–148))** 87 (54–162) 91 (55–154)* 106 (50-146)* 82 (53–135)
MAP 88 (72–97) 88 (71–99) 61 (51–69)*** 70 (50-79)* 71 (59-82) 76 (49–90) 68 (61–88)*
VTI 13.3 (9.4–16.5) 12.2 (8–18) 11.9 (8.1–17.3) 11.5 (8.5–13.5) 11.8 (7.9–13.3)* 11.6 (7.7–14.3)* 10.9 (7.5–14.7)*
VTI*HR 1002 (630-1159) 899 (537–1705) 1172 (806–1554) 952 (629–1377) 1053 (678–1262) 1082 (593–1516) 950 (616–1254)
  1. Tpeak, moment of maximum haemodynamic depression; HR, heart rate (beats minute-1); MAP, mean arterial pressure (mmHg); VTI, velocity time integral (centimetres)
  2. Data expressed as median (range)
  3. Values significantly different from pre-induction
  4. *0.01 < p < 0.05
  5. **0.001 < p < 0.01
  6. ***p < 0.001