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Table 1 Haemodynamic variables in dogs (n = 8) receiving a bolus of 5 mg/kg of propofol, administered over 30 s IV, at different time points

From: Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring

 

Pre-induction

30 s

Tpeak

55 (50–60) sec

90 s

120 s

150 s

300 s

HR

65 (50–120)

76 (50–130)

105 (70–148))**

87 (54–162)

91 (55–154)*

106 (50-146)*

82 (53–135)

MAP

88 (72–97)

88 (71–99)

61 (51–69)***

70 (50-79)*

71 (59-82)

76 (49–90)

68 (61–88)*

VTI

13.3 (9.4–16.5)

12.2 (8–18)

11.9 (8.1–17.3)

11.5 (8.5–13.5)

11.8 (7.9–13.3)*

11.6 (7.7–14.3)*

10.9 (7.5–14.7)*

VTI*HR

1002 (630-1159)

899 (537–1705)

1172 (806–1554)

952 (629–1377)

1053 (678–1262)

1082 (593–1516)

950 (616–1254)

  1. Tpeak, moment of maximum haemodynamic depression; HR, heart rate (beats minute-1); MAP, mean arterial pressure (mmHg); VTI, velocity time integral (centimetres)
  2. Data expressed as median (range)
  3. Values significantly different from pre-induction
  4. *0.01 < p < 0.05
  5. **0.001 < p < 0.01
  6. ***p < 0.001