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Table 1 Mean fold change and p-values of selected genes in whole blood at three time points

From: Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage

Gene function Gene name Whole blood
16 wpi 22 wpi 23 wpi
FC ± SEM p FC ± SEM p FC ± SEM p
Pattern Recognition Receptor TLR2 Toll-like receptor 2 1.11 ± 0.04 0.73 1.96 ± 0.28 0.02 1.98 ± 0.54 0.03
TLR4 Toll-like receptor 4 −1.41 ± 0.05 0.41 2.14 ± 0.42 0.02 2.00 ± 0.42 0.03
Complement Component C3 Complement component 3 1.57 ± 0.22 0.19 3.04 ± 0.91 0.02 4.74 ± 2.32 0.02
Interleukin IL1B Interleukin-1β −1.71 ± 0.03 0.02 1.66 ± 0.16 0.02 −1.24 ± 0.15 >  0.05
Acute Phase Protein SAA Serum Amyloid A 1.07 ± 0.35 0.73 5.00 ± 1.49 0.02 21.99 ± 18.03 0.03
LF Lactoferrin 1.05 ± 0.35 1.00 4.64 ± 2.64 0.06 13.70 ± 10.35 0.02
  1. Mean fold change (FC) with standard error of the mean (SEM) and p-value of differentially expressed genes in whole blood in the scrapie group. The mean fold change value is relative to the mean of the control group which is scaled to 1, at each of the different times (weeks) post inoculation