Expression of selected genes isolated from whole blood, liver and obex in lambs with experimental classical scrapie and healthy controls, showing a systemic innate immune response at the clinical end-stage

Table 1 Mean fold change and p-values of selected genes in whole blood at three time points

Gene function	Gene name		Whole blood
			16 wpi		22 wpi		23 wpi
			FC ± SEM	p	FC ± SEM	p	FC ± SEM	p
Pattern Recognition Receptor	TLR2	Toll-like receptor 2	1.11 ± 0.04	0.73	1.96 ± 0.28	0.02	1.98 ± 0.54	0.03
Pattern Recognition Receptor	TLR4	Toll-like receptor 4	−1.41 ± 0.05	0.41	2.14 ± 0.42	0.02	2.00 ± 0.42	0.03
Complement Component	C3	Complement component 3	1.57 ± 0.22	0.19	3.04 ± 0.91	0.02	4.74 ± 2.32	0.02
Interleukin	IL1B	Interleukin-1β	−1.71 ± 0.03	0.02	1.66 ± 0.16	0.02	−1.24 ± 0.15	> 0.05
Acute Phase Protein	SAA	Serum Amyloid A	1.07 ± 0.35	0.73	5.00 ± 1.49	0.02	21.99 ± 18.03	0.03
Acute Phase Protein	LF	Lactoferrin	1.05 ± 0.35	1.00	4.64 ± 2.64	0.06	13.70 ± 10.35	0.02

Mean fold change (FC) with standard error of the mean (SEM) and p-value of differentially expressed genes in whole blood in the scrapie group. The mean fold change value is relative to the mean of the control group which is scaled to 1, at each of the different times (weeks) post inoculation

ISSN: 1746-6148