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Table 3 The differences of the potential antigenic peptide in gB, gC and gD between Qihe547 and Bartha ADV. In the N terminus of ADV gB, there are antigenically important regions, such as (AA59-AA126, AA214-AA279, AA507-AA734) [21]. The extracellular region (AA23-AA453) of ADV gC plays an important role in ADV adsorption, neutralizing antibody generation and virus neutralization. gD also is the main target of ADV antibody. Mutation occurred in these regions may result antigen drift. Numerous AA mutations and potential antigenic peptides differences were found in gB, gC and gD of Qihe547, this may lead to immune failure

From: Genetic characterization and mutation analysis of Qihe547 Aujeszky’s disease virus in China

Name Qihe547a Barthab
gB 89IDGAVSP95 65ASASPTPVPGSP76
79TPNDVSAE86
433EAIDAIYQ440
gC 43AGELSPSP50
52STPEPVSG59
43AGELSPSPPPTPAPA57
gD 62LEDPCGVVALISDPQVDR79
81LNEAVAHR88
62LEDPCGVAALISDPQVDRLLSEAVAHR88
  1. athe potential antigenic peptide only in Qihe547
  2. bthe potential antigenic peptide only in Bartha