Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals

Table 3 Cytotoxic T cell responses in cattle immunized with the Muguga cocktail on the three T. parva component strains as targets

	Muguga 4230	Serengeti 4229	Kiambu 5 4228
BG042	26^a	18	13
BG051	40^a	28	34
BG056	27^a	22	15
BH047	9	11	5

Cytotoxic T cell responses by vaccine immunized animals using autologous PBMC infected with the three different T. parva component strains as targets. Each CTL was titrated on a fixed number of target cells. The effector/target ratio of 10:1 is shown and each value is deduced from an effector (CTL) titration curve as shown in Fig. 1. Statistical comparison of parameters from fitted curves were used to test differences in cytotoxicity between targets. (^a) significant higher than for both other targets for each animal (p < 0.001)

ISSN: 1746-6148