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Table 1 Mucosal S100A12 and MPO levels in relation to histopathologic changes in the duodenum and ileum

From: S100A12 concentrations and myeloperoxidase activities are increased in the intestinal mucosa of dogs with chronic enteropathies

Histopathological findings n Severity groups S100A12 (μg/L)
Median (IQR)
P valuea MPO (ΔA/min)
Median (IQR)
P valuea
Duodenum 35      
 Total histopathological severity 35 Insignificant (n = 16) 33.65 (7.41-155.9) 0.2240 0.9 (0.2-2.95) 0.006 b
Mild (n = 15) 53.12 (10.07-164.85) 1.49 (0.14-4.55)
Moderate (n = 4) 52.22 (42-179.6) 7.54 (0.94-17.16)
Morphological criteria 35      
 Villus stunting 35 Normal (n = 20) 44.18 (7.41-155.9) 0.4090 1.23 (0.14-4.55) 0.1439
Mild (n = 10) 45.02 (19.51-179.6) 1.21 (0.37-3.88)
Moderate (n = 3) 56.27 (42.72-164.85) 2.16 (1.63-11.62)
Severe (n = 2) 26.04 (10.07-42) 8.85 (0.54-17.16)
 Epithelial injury 35 Normal (n = 30) 48.68 (7.41-164.85) 0.9122 1.23 (0.14-11.62) 0.0455 b
Mild (n = 3) 28.94 (19.51-179.6) 1.58 (0.94-2.9)
Moderate (n = 2) 34.38 (26.76-42) 9.82 (2.48-17.16)
 Crypt distension 35 Normal (n = 29) 42.96 (7.41-164.85) 0.4156 1.29 (0.14-17.16) 0.0694
Mild (n = 5) 67.87 (19.75-179.6) 0.94 (0.63-1.63)
Moderate (n = 1) 42.72 11.62
 Lacteal dilation 35 Normal (n = 19) 28.94 (7.41-155.9) 0.0889 1.24 (0.2-17.16) 0.0708
Mild (n = 10) 54.7 (12.49-144.29) 1.07 (0.14-2.48)
Moderate (n = 6) 53.07 (42.72-179.6) 2.81 (0.94-11.62)
 Mucosal fibrosis 35 Normal (n = 31) 42.96 (7.41-179.6) 0.9191 1.36 (0.14-17.16) 0.6993
Mild (n = 4) 63.88 (10.07-93.02) 0.83 (0.54-3.88)
Inflammatory criteria 35      
 Intraepithelial lymphocytes 35 Normal (n = 23) 42.96 (7.41-164.85) 0.9381 1.24 (0.14-17.16) 0.7695
Mild (n = 10) 36.44 (11.53-179.6) 1.12 (0.37-4.55)
Moderate (n = 2) 53.07 (44.42-61.71) 2.41 (1.36-3.46)
 Lamina propria LPC 35 Normal (n = 2) 99.19 (42.48-155.9) 0.1963 0.53 (0.2-0.87) 0.0975
Mild (n = 15) 24.83 (7.41-164.85) 1.24 (0.36-2.95)
Moderate (n = 15) 50.94 (10.07-179.6) 1.36 (0.14-11.62)
Severe (n = 3) 61.71 (42-93.02) 3.46 (0.77-17.16)
 Lamina propria eosinophils 35 Normal (n = 22) 58.99 (10.07-179.6) 0.0516 0.92 (0.14-3.46) 0.0004 b
Mild (n = 5) 19.75 (7.41-42.96) 0.91 (0.64-2.95)
Moderate (n = 8) 43.33 (26.76-78.03) 3.39 (1.22-17.16)
 Lamina propria neutrophils 35 Normal (n = 20)
Mild (n = 7)
Moderate (n = 6)
Severe (n = 2)
42.72 (7.41-102.46)
61.1 (19.51-155.9)
47.92 (24.83-179.6)
113.28 (61.71-164.85)
0.1542 1.07 (0.36-17.16)
1.49 (0.2-3.88)
1.4 (0.14-11.62)
2.81 (2.16-3.46)
0.7326
 Lamina propria macrophage 35 Normal (n = 32) 42.84 (7.41-164.85) 0.0439 b 1.39 (0.14-17.16) 0.1786
Mild (n = 3) 155.9 (44.2-179.6) 0.94 (0.2-1.36)
Ileum 12      
 Total histopathological severity 12 Insignificant (n = 8) 106.93 (9.59-317.21) 0.9816 1.91 (0.34-2.83) 0.3260
Mild (n = 4) 125.92 (16.36-151.79) 2.3 (0.79-7.01)
Morphological criteria 12      
 Villus stunting 12 Normal (n = 7) 120.84 (9.59-317.21) 0.7443 2.04 (0.34-2.83) 0.3447
Mild (n = 5) 116.24 (16.36-151.79) 1.77 (0.69-7.01)
 Epithelial injury 12 Normal (n = 10) 118.54 (9.59-317.21) 0.4956 1.91 (0.34-3.23) 0.2387
Moderate (n = 2) 84.07 (16.36-151.79) 4.18 (1.36-7.01)
 Crypt distension 12 Normal (n = 11) 116.24 (9.59-317.21) 0.6913 2.04 (0.34-7.01) 0.4692
Moderate (n = 1) 120.84 0.79
 Lacteal dilation 12 Normal (n = 8) 106.93 (9.59-317.21) 0.9881 1.56 (0.34-2.83) 0.2034
Mild (n = 4) 125.92 (16.36-162.43) 2.63 (0.79-7.01)
 Mucosal fibrosis 12 Normal (n = 12) 118.54 (9.59-317.21) 1.91 (0.34-7.01)
Inflammatory criteria 12      
 Intraepithelial lymphocytes 12 Normal (n = 6) 109.23 (9.59-162.43) 0.6809 1.42 (0.34-2.81) 0.1787
Mild (n = 6) 123.62 (16.36-317.21) 2.3 (0.69-7.01)
 Lamina propria LPC 12 Normal (n = 4) 118.78 (47.08-162.43) 0.5561 2.12 (0.44-2.81) 0.9999
Mild (n = 4) 68.6 (9.59-317.21) 1.81 (0.34-7.01)
Moderate (n = 4) 123.62 (47.32-151.79) 1.56 (0.69-3.23)
 Lamina propria eosinophils 12 Normal (n = 9) 130.99 (9.59-317.21) 0.2514 1.77 (0.34-3.23) 0.2019
Mild (n = 2) 72.35 (47.08-97.62) 1.63 (0.44-2.81)
Moderate (n = 1) 16.36 7.01
 Lamina propria neutrophils 12 Normal (n = 9) 116.24 (9.59-317.21) 0.7430 2.04 (0.34-3.23) 0.5989
Mild (n = 3) 120.84 (16.36-151.79) 1.36 (0.79-7.01)
 Lamina propria macrophage 12 Normal (n = 12) 118.54 (9.59-317.21) 1.91 (0.34-7.01)
  1. Association between mucosal S100A12 concentrations and MPO activities with severity of histopathological findings in the duodenum and ileum of dogs with CE. Statistical differences were calculated based on the log-transformed values of S100A12 and MPO. Untransformed values are reported as median (IQR)
  2. n sample size, IQR interquartile range, LPC lymphocytes/plasma cells
  3. aANOVA test after logarithmic transformation of original values
  4. bstatistically significant association