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Table 5 Observed interference effects of bilirubin, hemoglobin, lipid on triplicate CRP measurement with the POCT

From: Evaluation of a novel quantitative canine species-specific point-of-care assay for C-reactive protein

Interferent

Mean CRPcontrol [mg/l] ± SD

Mean CRPtest [mg/l] ± SD

Mean bias [mg/l]

%Biasobs

%Biasobs < TEdes (29.6%)

%Biasobs < TEopt (14.8%)

Bilirubin

800 mg/l

37.6 ± 5.6

39.8 ± 0.4

2.2

5.8

Yes

Yes

Hemoglobin

4 g/l

29.5 ± 1.7

30.1 ± 4.1

0.6

2.0

Yes

Yes

Soy bean emulsion

8 g/l

35.1 ± 1.4

39.1 ± 0.8

4.0

11.3

Yes

Yes

  1. Test samples (CRPtest) spiked with the interfering substances were compared to control samples (CRPcontrol) spiked with equal volume of the diluent used in the test sample. %Biasobs (observed bias) for the interfering substance was acceptable if %Biasobs < desired total allowable error (TEdes) and excellent if %Biasobs < optimal total allowable error (TEopt) [32]
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BMC Veterinary Research

ISSN: 1746-6148

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