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Table 3 Allelic and genotypic distribution of non-synonymous mutation found in LGI1–4 in familial spontaneous epileptic cats (FSECs) and controls

From: Molecular cloning and characterization of the family of feline leucine-rich glioma-inactivated (LGI) genes, and mutational analysis in familial spontaneous epileptic cats

  Nucleotide Amino Acid SIFT prediction PP2 prediction PROVEAN prediction Group (n) Genotype frequencies Allele frequencies
LGI3        C/C C/G G/G f(C) f(G)
  c.97C > G p.P33A Deleteriouss Benign Neutral FSECs(8) 8 0 0 1 0
       Controls(8) 7 1 0 0.9375 0.0625
LGI4        G/G G/A A/A f(G) f(A)
  c.49G > A p.A17T Tolerated Unknown Neutral FSECs(8) 8 0 0 1 0
       Controls(8) 7 1 0 0.9375 0.0625
        G/G G/A A/A f(G) f(A)
  c.145G > A p.E49K Tolerated Benign Neutral FSECs(8) 5 3 0 0.8125 0.1875
       Controls(8) 8 0 0 1 0
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