Fig. 2

Age-related differences in miR-34a expression exist in urine samples from normal dogs and those with lower urinary tract disease (LUTD) but not in urine samples from dogs with transitional cell carcinoma (TCC) of the bladder. Urine miR-34a expression correlated strongly with age in both the normal group (a) and the LUTD group (b), but not in the TCC group (c). There were no age-related differences observed in let-7c, miR-16, miR-103b, or miR-106b expression (data not shown). A correlation between age and miRNA expression was not observed in canine blood samples (data not shown). Pearson Product Moment Correlation was used to generate these data